Mifepristone Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of mifepristone powder in China. We warmly welcome yuo to wholesale bulk mifepristone powder for sale here from our factory. Quality products and reasonable price are available.

What Is Mifepristone
Mifepristone powder, a western medicine name, belongs to the category of anti-early pregnancy drugs. It can be used for sexual life without contraceptive measures or contraceptive failure after using contraceptive measures. Usually, we see RU38486, Lunarette, or RU486 is also mifepristone. It is combined with prostaglandin drugs to terminate a pregnancy within 49 days of incubation. It is used for anti-early pregnancy, menstruation termination, intrauterine induction of fetal death, and gynecological operations, such as placement and removal of intrauterine devices, endometrial specimens, laser separation of the abnormal cervical canal, and Cervical dilation and curettage.
As a new type of antiprogestin, mifepristone has antiglucocorticoid activity but no progestogen, estrogen, androgenic or antiestrogenic activity. Mifepristone has the effects of anti-fertilized egg implantation, inducing menstruation, and promoting cervical ripening. Its mechanism of promoting menstruation and stopping pregnancy is mainly to block the effect of progesterone by competing with the progesterone receptor in the endometrium. Compared with the affinity of the progesterone receptor, it is five times stronger than that of progesterone. In daily life, the application of mifepristone has become more extensive, so there are more and more good and bad suppliers in the market. If you want to find pure mifepristone, you can search Xi'an Sonwu.

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Where To Buy Mifepristone
Xi'an Sonwu Biotech Co. ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company's principle. Xi'an Sonwu strictly controls product quality, which means selection starts from raw materials. Besides, Xi'an Sonwu handles every detail and reduces the cost to the maximum extent so that customers can get a cost-effective product. Based on these, customers have given much good feedback to products. So look for Xi'an Sonwu Biotech Co. ltd. when buying mifepristone.
Xi'an Sonwu not ensures the product's quality but also supplies the samples. Please check the quantity.

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Mifepristone Pharmacological Effect

1. Anti-progesterone effect

(1) Effects on follicles and corpus luteum
Using mifepristone in the menstrual cycle or the late follicular phase can reduce the secretion of luteinizing hormone and follicle-stimulating hormone, thereby inhibiting the growth of follicles, shrinking the dominant follicles, and prolonging the follicular phase, which means that anovulation occurs. If the drug is only used in the early follicular phase or just before ovulation, it will not affect follicular development and ovulation. In the mid-luteal phase, it can directly inhibit the amplitude and frequency of LH pulses, thereby having the effect of luteinizing. Mifepristone has a direct inhibitory effect on the development of follicles. In the early follicles, it may inhibit the activity of 17-hydroxylase in granulosa cells. In addition to the immediate impact on the middle and late ovaries, it inhibits FSH and LH effects. Mifepristone can hinder the function of the luteal phase, mainly inhabiting the role of the luteal step in the middle and late stages, and has no pronounced effect on the early luteal phase. Large doses can dissolve the corpus luteum, significantly reduce the secretion of estrogen and progesterone, shorten the luteal phase, and bring about early menstruation.

(2) Effects on the endometrium
The effect on the endometrium is mainly due to its high affinity with the endometrial progesterone receptor, which competitively blocks the biological activity of progesterone. Mifepristone can antagonize or even reverse the effect of progesterone on tissue factor expression in endometrial stromal cells. It significantly impacts decidual tissue, degeneration of decidual cells, reduction of mitotic figures, secondary degeneration of villi, human chorionic gonadotropin decline, and then luteal function hypofunction, estrogen, and progesterone secretion decreased. Therefore, the synthesis and secretion of endogenous prostaglandins increase in decidual degeneration and decidual hemorrhage and shedding.

(3) Effect on uterine smooth muscle
The balance between progesterone and prostaglandins regulates the spontaneous activity of the uterus. Progesterone acts to quiet the uterus. The ability of mifepristone to competitively bind to progesterone receptors is three times stronger than that of progesterone, which blocks the inhibitory effect of progesterone on uterine muscle and increases the sensitivity of uterine myometrium excitation. In a typical early pregnancy, the cervical collagen tissue is rich, and the cervix is closed to protect the fetus. However, under the action of mifepristone, the progesterone receptor is occupied, the biological activity of progesterone is weakened, and the inhibition of collagen decomposition by progesterone is lost, causing The tension of the cervix is reduced, so it is clinically used for medical abortion and induction of labor.

2. Anti-glucocorticoid effect

Mifepristone produces antiglucocorticoid effects at both high and low doses. That shows that mifepristone can inhibit cell proliferation and GRmRNA expression induced by dexamethasone and present a direct or indirect anti-cell proliferation effect. Mechanisms of mifepristone's antiglucocorticoid-like effects include:
Enhance the stability of GR-heat shock protein 90 complex and prevent the combination of glucocorticoids and GR;
Receptor conformational changes induced by GR binding fail to activate transcription.

(1) Effects on the function of the hypothalamus-pituitary-adrenal axis
Mifepristone affects the function of the human hypothalamus-pituitary-adrenal axis in a dose-dependent manner. In vitro studies have found that mifepristone has a particular affinity with human progesterone receptors and GR, so it exhibits dual activities of anti-progesterone and anti-glucocorticoid. Mifepristone may compete with GR only at higher doses. When the concentration ratio of serum mifepristone and corticosteroids is ≥10:1, mifepristone shows a pronounced anti-glucocorticoid effect. Therefore, mifepristone at a standard therapeutic dose mainly exhibits an anti-progesterone effect. Only at high doses does it demonstrate an anti-glucocorticoid impact, so it will not cause damage to adrenal function.

(2) Effect on breast, pancreas, and endometrium
Glucocorticoids promote the expression of target genes, glucocorticoid-regulated kinases, in normal mammary epithelial cells and bad mammary cells and inhibit apoptosis induced by growth factor withdrawal. The anti-glucocorticoid effect of mifepristone can increase the apoptosis rate by 4.5 times. Throughout the menstrual cycle, GR is always highly expressed in the endometrial stroma, also described in lymphocytes and fibroblasts, but completely absent in the nucleus of endometrial glands.

Mechanism Of Action Of Mifepristone
Mifepristone powder is a progesterone receptor antagonist at the molecular level, which binds to PR to block the physiological effects of progesterone. The human progesterone receptor is composed of 934 amino acids, and there are three functional regions in the molecule: starting from the 567th amino acid, it is a DNA binding region; the critical hormone region occupies a more extensive area at the carboxyl end of the molecule; Functional regions related to chemical and transcriptional activation. Human progesterone receptors typically bind to heat shock proteins 90 and 70 without hormones. When progesterone enters the cell and attaches to the receptor, it is first transformed by the receptor, releases heat shock protein, then dimerizes to form a dimer, and then binds to the corresponding hormone response factor on the DNA to activate the transcription activator, thereby passing mRNA synthesizes protein, producing hormonal effects.

Mifepristone has a high affinity for progesterone receptors. When the two are combined, a complex of mifepristone + receptor + heat shock protein is formed. The complex then enters the nucleus, after which the nucleoproteins and heat shock proteins bind. The interaction between receptors, shock proteins, and nucleoproteins is enhanced so that they cannot interact with DNA. Mifepristone can cause hyperphosphorylation of progesterone receptors, so gene transcription cannot be completed even after progesterone receptors bind to DNA. That means that the drug will inhibit the function of the corpus luteum, affect the secretion of estrogen and progesterone by the ovary, and prevent ovulation. In addition, the drug can also increase the mucus concentration in the cervix, so that sperm cannot penetrate the cervix and enter the uterine cavity to combine with the egg to play a contraceptive effect.

What Are The Uses Of Mifepristone

1. Termination of pregnancy

(1) Non-surgical termination of early pregnancy
The combination of mifepristone and misoprostol to terminate early pregnancy is considered to be an ideal method of non-surgical abortion, which is characterized by a high abortion rate, strong safety, and few adverse reactions. Note that mifepristone + misoprostol has occurred in the case of Clostridium sordellii toxic shock syndrome.

(2) Non-surgical termination of second-trimester pregnancy
Mifepristone combined with misoprostol can be used to terminate a pregnancy at 16 to 24 weeks, with a definite curative effect, better than rivals for labor induction. It can be used as a routine method in the clinical promotion.

(3) Missed abortion
Mifepristone used alone or in combination with prostaglandins has a high rate of spontaneous abortion, less vaginal bleeding, and is safer than negative pressure aspiration, with an effective rate of 74% to 93%. It is a practical, secure, and reliable method for treating missed abortions of 12 to 27 weeks of menopause, with a success rate of 97.5%.

(4) Induction of stillbirth
Mifepristone softens and dilates the cervix and induces labor after intrauterine death. Studies have shown that the effect of mifepristone alone or in combination with misoprostol is better. Still, if the stillbirth has not been delivered within 72 hours, it is necessary to switch to other methods to induce labor.

(5) induction of labor
Mifepristone combined with misoprostol is used to promote cervical ripening in full-term pregnancy. The effect on decidua and villi is relatively mild, and it is not enough to affect the nutritional intake of fetal blood supply. The application is relatively safe and reliable. And compared with the clinical effect of low-dose oxytocin commonly used in the past, it can significantly shorten the labor process and reduce the incidence of fetal distress and the rate of neonatal asphyxia.

2. Contraception

(1) Routine contraception
Studies have shown that mifepristone alone provides good long-term contraception. When the dose exceeds 2mg/day, it will inhibit ovulation.

(2) Emergency contraception
Mifepristone can prevent follicle development, inhibit ovulation, induce ovarian granulosa cell apoptosis, and prevent embryonic development. Within 120 hours after sexual intercourse, taking 10mg, 25mg, 50mg, or 600mg of mifepristone at a time can effectively prevent pregnancy.

3. Disease treatment

Mifepristone has the effects of anti-endometrial proliferation, menopause, and ovulation inhibition. It can treat uterine fibroids, endometriosis, dysfunctional uterine bleeding, bad endometrial cells, cervical and ovarian cells, etc.

(1) Uterine fibroids
Clinical studies have shown that treating leiomyoma with a 5-50mg/d dose of mifepristone for 3-6 months can reduce its volume by 26%-74%; menopause rate is 63%-100%, dysmenorrhea, menstrual flow Symptoms of multiple and pelvic compression were reduced or alleviated.

(2) Endometriosis
Mifepristone has an antiproliferative effect on the endometrium, reducing endometrial angiogenesis, blood flow in the myometrium, thinning the endometrium, and atrophy of the spiral arteries. It is clinically used to treat endometriosis, and amenorrhea after medication, shrink the lesion and relieve pain.

(3) Uterine and ovarian disease
Mifepristone (200mg/d) may have a particular effect on PR-positive endometrial adenocarcinoma or sarcoma and can stabilize the condition of some patients.

(4) Inhibit breakthrough bleeding
Used to reduce irregular bleeding caused by progestin-only contraception. Mifepristone can induce menopause, and intermittent use of mifepristone has been used to minimize irregular bleeding caused by progestin alone.

What Are The Side Effects Of Mifeprex
The most common and severe side effects of mifepristone are endometrial thickening, leading to massive bleeding. Followed by vaginal dryness, loss of libido, hot flashes, joint pain, rare liver damage, hypothyroidism, acne, and weight gain wait. Long-term use of mifepristone can cause an unopposed estrogen environment, resulting in abnormal endometrial hyperplasia. The larger the dose, the longer the time, and the more pronounced the hyperplasia. It eventually leads to removing the uterus and its appendages, contrary to the original purpose of taking medicine. In addition, when mifepristone is used, liver function damage may occur. During medication, ALT and AST exceed three times the standard upper limit, and total bilirubin exceeds two times the normal upper limit. Other reasons cannot explain it. It should be considered to stop the medicine.

Factory
1. Xi'an Sonwu Biotech Co., Ltd has its factory to produce, manufacture and store the products, so have adequate stock. Xi'an Sonwu has a well-ordered, clean and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.

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