ISRIB Raw Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of isrib raw powder in China. We warmly welcome yuo to wholesale bulk isrib raw powder for sale here from our factory. Quality products and reasonable price are available.

ISRIB Peptide

ISRIB raw powder trans-isomer, also known as trans-ISRIB, CAS number 1597403-47-8, chemical name N, N′-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]. Its molecular formula is C₂₂H₂₄Cl₂N₂O₄, and its molecular weight is approximately 451.34 g/mol. It is a synthetic small-molecule compound with a well-defined stereoconfiguration. Structurally, it contains a trans-substituted cyclohexane skeleton with chlorophenoxyacetamide structures on both sides. This relatively symmetrical structure is closely linked to its biological activity, enabling it to interact with binding sites on specific protein complexes. The trans isomer and cis isomer have different spatial configurations. Studies show that trans-ISRIB regulates integrated stress responses more strongly, making it a widely used research tool in this field. As small-molecule tool compounds with clearly defined targets, research focuses not on traditional nutritional supplementation or general cell stimulation, but on how stress signals affect cellular function by modulating the initiation of intracellular protein translation. Their chemical characteristics also support structure-activity relationship studies, allowing researchers to explore novel eIF2B regulatory molecules by examining relationships among molecular configuration, substituents, protein-binding capacity, and biological activity. Commonly used trans isomers are typically white to off-white solids or crystalline powders with low water solubility; stock solutions can be prepared in appropriate organic solvents based on experimental needs. Specific solubility varies by solvent, temperature, and product batch. For raw material procurement and experimental applications, it is recommended to focus on trans isomer identity, chemical purity, batch consistency, solvent suitability, and storage stability, referring to the actual COA, SDS, and product technical data. With its clear chemical structure, well-defined research targets, and established applications in cell signal regulation, it has become a representative small-molecule research tool for protein synthesis regulation, cellular stress research, and neurobiological experiments.

As one of the most popular products, Trans-ISRIB powder has received many positive comments and feedback from customers. Customers are most attracted to its high quality. In addition, Xi'an Sonwu offers a highly competitive price. For more information, contact Xi'an Sonwu Biotech Co., Ltd.

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ISRIB Buy Online

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ISRIB Mechanism of Action

ISRIBs regulate the Integrated Stress Response (ISR), a cellular regulatory network that coordinates external stress, protein synthesis, and cellular adaptation. When cells encounter endoplasmic reticulum stress, amino acid deficiency, virus-related stimuli, or other stressors, ISRs alter overall protein translation levels and adjust the expression of certain stress-related proteins to help cells adapt to environmental changes. However, persistent or abnormal stress signals can also interfere with normal protein synthesis and further affect cellular physiological functions. They act at key nodes in this regulatory network and are therefore widely used to study protein-synthesis recovery, cellular homeostasis regulation, and downstream signaling changes under stress. Unlike compounds that directly stimulate cell growth or broadly enhance protein synthesis, ISRIBs' research value lies primarily in their ability to intervene in specific regulatory mechanisms, enabling researchers to more clearly analyze the relationship between ISRs and cellular function. Neuroscience is one of its most promising application areas. Protein translation is involved in synaptic plasticity, memory formation, and long-term neural adaptation; therefore, it is used to study how stress signals affect learning and memory. Some animal studies show that it can improve spatial learning, fear memory, and cognitive deficits related to traumatic brain injury in specific experimental models, offering important clues for studying translational regulation in the nervous system. It can also be used to explore endoplasmic reticulum stress, protein homeostasis imbalances, stress granule formation, and changes in neuronal function. For cell biology laboratories, neuroscience research teams, and drug discovery institutions, its advantage lies in its ability to conduct multi-level research around the same key pathway, from basic cell experiments to animal disease models and candidate molecule screening.

ISRIB raw powder is primarily related to regulating the eukaryotic translation initiation factor eIF2B. Under normal conditions, eIF2 delivers initiating methionine-1-tRNA to the ribosome. At the same time, eIF2B promotes the conversion of eIF2 from a GDP-bound state to a GTP-bound active state, allowing it to continue participating in subsequent protein translation initiation. When cells sense stress signals, kinases such as PERK, GCN2, PKR, and HRI can promote eIF2α phosphorylation. Phosphorylated eIF2 inhibits eIF2B's nucleotide exchange function, reducing overall translation initiation and altering the expression of stress-related proteins such as ATF4. This mechanism helps cells reallocate resources under stress, but if stress signals persist, it can also lead to abnormal regulation of protein synthesis. A key characteristic of ISRIBs is that they primarily act on downstream regulatory nodes in this process, rather than simply blocking all upstream stress sensors. Studies show that it can bind specific regions of eIF2B, promoting and stabilizing its active assembly state and enhancing eIF2B's regulatory capacity. eIF2B is a protein complex composed of multiple subunits, and its active assembly state is crucial for maintaining its normal function. It binds to interfaces between subunits, helping stabilize the active structure; therefore, it is often figuratively described as a "molecular staples" that connects and stabilizes protein complexes. In this way, it can alleviate the inhibitory effect of phosphorylated eIF2 on eIF2B, restore some translation initiation activity under appropriate experimental conditions, and alter downstream stress responses. This mechanism also explains why it can be used to study the connection between protein synthesis, cellular stress, and neural function. It's important to note that it does not completely shut down the integrated stress response, nor does it indiscriminately enhance the synthesis of all proteins; its effectiveness is influenced by factors such as cell type, stress intensity, eIF2B status, and experimental conditions. Because they can act on specific molecular regulatory nodes, they have become important tool compounds for studying eIF2B function, translation initiation control, and stress signaling.

ISRIB transisomers have applications across multiple research areas, including cellular stress, protein translation, neuroscience, and drug development. For laboratories conducting cellular signaling research, it can be used to analyze changes in translation initiation under different stress conditions, study the relationship between eIF2B activity and the expression of stress-related factors such as ATF4, and observe the cellular adaptation process after stress stimulation. By combining it with different stress-induced conditions, gene interventions, or other signaling-pathway regulatory tools, researchers can compare cellular responses across treatments to determine whether specific biological changes relate to ISR regulation. In endoplasmic reticulum stress and protein homeostasis studies, it can be used to explore how cells respond to misfolded protein accumulation, translational stress, and persistent stress signals, and to analyze how these changes relate to cellular function. For research teams focused on stress granulation, protein synthesis recovery, and regulation of cellular homeostasis, it can provide a clear mechanistic entry point for experimental design. Neuroscience and cognitive research is another important application of ISRIB. Memory formation and synaptic plasticity require precise regulation of protein synthesis, and abnormal ISR signaling may affect these processes. Animal studies have used it to explore learning and memory, long-term memory formation, and cognitive changes after traumatic brain injury, observing positive results in some models. This makes it a commonly used tool for studying neuronal translational regulation, synaptic function, and stress-related cognitive changes. Furthermore, researchers can also use ISRIB to explore molecular mechanisms related to eIF2B dysfunction, cellular stress imbalance, and neurodegenerative processes, providing experimental evidence for subsequent target validation and candidate compound research.

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Xi'an Sonwu production factory is well-equipped, clean, and tidy, with sufficient stock. Under the company's leadership, researchers focus on developing new products. The facility includes a laboratory testing environment, advanced testing equipment, and professional testers, with a strict focus on delivering reliable product data and a high-quality customer experience.

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Xi'an Sonwu has 10 years ' experience in product development, production and sales.

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