Fmoc-OSu Powder

What Is Fmoc-OSu

Fmoc-OSu Powder, also known as 9-fluorenylmethoxycarbonyl-N-hydroxysuccinimide ester, is a chemical reagent commonly used in peptide synthesis. It is used for the protection of amino groups in the process of creating peptide bonds. Fmoc-OSu reacts with amino groups to form stable Fmoc-amino derivatives that can be utilized for the stepwise assembly of peptides in solid-phase synthesis.

This reagent allows for selective deprotection of the Fmoc group, enabling the addition of amino acids in a specific order to build the desired peptide sequence. Fmoc-OSu is widely utilized in research and pharmaceutical settings for the production of custom peptides for various applications, including drug development and biochemical studies.

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Fmoc-OSu Supplement

Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw materials. Besides, we handle every detail and reduce the cost to the maximum extent, then our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So you can look for Xi'an Sonwu Biotech Co. Ltd. when you need Fmoc-OSu supplement.

Xi'an Sonwu completely makes sure of the product's quality, so samples can be supplied. Here is the quantity.

What Is The Use Of Fmoc-OSu

Fmoc-OSu, also known as 9-flunylmethoxycarbonyl-N-hydroxysuccinimide ester, is commonly utilized in peptide synthesis. It serves as a reagent for protecting amino groups during the creation of peptide bonds. When used, Fmoc-OSu reacts with amino groups to form stable Fmoc-amino derivatives, which can be employed for the stepwise assembly of peptides in solid-phase synthesis.

The main utility of Fmoc-OSu lies in its ability to selectively deprotect the Fmoc group, allowing amino acids to be added in a specific order to construct the desired peptide sequence. This process enables the controlled and precise synthesis of peptides, which is valuable in various fields such as pharmaceutical research and drug development.

How Does Fmoc Work

Fmoc (9-fluorenylmethyloxycarbonyl) is a protecting group commonly utilized in peptide synthesis to shield the amino group of amino acids. During the process, Fmoc is typically attached to the N-terminus of the amino acid chain on a solid support. This step prevents unwanted reactions with the amino group during the peptide elongation process.

Fmoc is known for its compatibility with a variety of solvents and reagents commonly used in peptide synthesis. It can also be removed under mild, basic conditions, such as treatment with piperidine in organic solvents, allowing for selective deprotection of the amino group when necessary. This selectivity enables the controlled addition of amino acids in the desired sequence during the stepwise assembly of the peptide chain. Overall, Fmoc serves as a valuable tool in solid-phase peptide synthesis, contributing to the precision and efficiency of peptide production in both research and pharmaceutical settings.

Why Fmoc Is Better Than BOC

Fmoc (9-fluorenylmethyloxycarbonyl) and BOC (tert-butyloxycarbonyl) are both commonly used protecting groups in peptide synthesis, and each has its own strengths and limitations. Fmoc is often preferred over BOC for several reasons:

1. Compatibility: Fmoc chemistry is more compatible with a wider range of solvents and reagents commonly used in peptide synthesis, providing greater flexibility in the synthetic process.

2. Deprotection: Fmoc can be removed under mild, basic conditions, such as treatment with piperidine in organic solvents, enabling selective deprotection of the amino group. This allows for the controlled addition of amino acids in the desired order during peptide assembly.

3. Automation: Fmoc-based solid-phase peptide synthesis is more amenable to automation due to its compatibility with a variety of reaction conditions and the straightforward deprotection steps.

4. Side Reactions: Fmoc is associated with fewer side reactions compared to BOC, leading to higher overall purity of the synthesized peptides.

While Fmoc is often favored for its versatility and compatibility, it's important to note that the choice between Fmoc and BOC may depend on the specific requirements of the peptide synthesis process and the desired properties of the final peptide product.

How Is Fmoc Removed

Fmoc (9-fluorenylmethyloxycarbonyl) is typically removed during solid-phase peptide synthesis under mild, basic conditions. The most common method involves treating the Fmoc-protected amino acid with piperidine in a suitable organic solvent, such as N,N-dimethylformamide (DMF). The piperidine reacts with the Fmoc group, leading to its cleavage and the release of the free amino group of the amino acid. This deprotection step allows for the selective addition of the next amino acid in the desired sequence.

The reaction conditions are carefully controlled to ensure the selective removal of the Fmoc group while minimizing unwanted side reactions. After deprotection, the peptide synthesis cycle can continue with the addition of the next Fmoc-protected amino acid, ultimately leading to the synthesis of the desired peptide sequence. Overall, the removal of Fmoc is a critical step in solid-phase peptide synthesis, enabling the precise and controlled construction of peptides with specific sequences and functionalities.

Precautions of the Fmoc-Osu

Fmoc-OSu, or 9-fluorenylmethyloxycarbonyl-N-hydroxysuccinimide ester, is a chemical reagent commonly used in peptide synthesis. When working with Fmoc-OSu, it is important to take the following precautions:

1. Personal Protective Equipment: Always wear appropriate personal protective equipment (PPE) when handling Fmoc-OSu, including lab coat, gloves, and safety glasses.

2. Handling and Storage: Store Fmoc-OSu in a cool, dry place and handle it in a well-ventilated area to minimize exposure to the vapors.

3. Inhalation and Ingestion: Avoid breathing in the dust, vapors, or aerosols of Fmoc-OSu, and do not ingest it.

4. Skin Contact: Minimize skin contact with Fmoc-OSu Powder by wearing protective gloves and appropriate clothing. In case of contact, immediately take off sullied dress and wash the impacted region with cleanser and water.

5. Eye Contact: In case of eye contact, flush the eyes thoroughly with water for at least 15 minutes and seek medical attention.

6. Spills and Disposal: Clean up spills of Fmoc-OSu immediately, following appropriate safety procedures and using suitable absorbent materials. Dispose of Fmoc-OSu and any contaminated materials according to local regulations.

7. First Aid: Make sure that the appropriate first aid measures are readily available in the laboratory in the event of an accidental exposure to Fmoc-OSu.

The goal of these precautions is to reduce risk associated with handling Fmoc-OSu and to ensure the safety of laboratory personnel. It is important to consult the safety data sheet and other relevant safety documentation for specific information regarding the safe handling, storage, and disposal of Fmoc-OSu. Additionally, always follow the guidelines and policies established by your institution or laboratory regarding the use of chemical reagents.

Factory

1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.

2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.

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Logistics Update

In addition to guaranteeing product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

Company's Profile

Xi'an Sonwu Biotech Co., Ltd is a professional Chinese manufacturer and products supplier. It was founded in 2012 and is located in the Hi-Tech Industrial Zone, Xi'an City, Shannxi Province, China. It pays all attention to the development, research, and production of food additives, plants, extract, APl, and other ingredients of health care products. The company supplies five kinds of raw material products: Anti-hair loss Powders, Nootropic, API, Muscle Building products, and Plant Extract. Xi'an Sonwu sincerely believes that the premise of great cooperation is the best service and good quality. So, welcome your inquiry.

And if you want to know the Fmoc-OSu Powder price or you need Fmoc-OSu Supplement, please contact XI'an Sonwu.

Email: sales@sonwu.com

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