Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of api powder dasantafil in China. We warmly welcome yuo to wholesale bulk api powder dasantafil for sale here from our factory. Quality products and reasonable price are available.
What Is Dasantafil
API powder dasantafil, also referred to as SCH-446132, is a pharmacologically active small-molecule drug. 7-[(3-bromo-4-methoxyphenyl)methyl]-1-ethyl-8-[[(1R,2R)-2-hydroxycyclopentyl]amino]-3-(2-hydroxyethyl)purine-2,6-dione] is its systematic chemical name. This name describes a chemical structure that includes a hydroxycyclopentylamino moiety, a hydroxyethyl side chain, a bromomethoxybenzyl substituent, and a heterocyclic scaffold containing nitrogen. The molecule's electronic distribution, intermolecular interactions, spatial arrangement, and possible biological activity are all influenced by the bromine atom, methoxy group, hydroxyl group, and different nitrogen-containing functional groups. Chemical databases identify it as a particular purinedione derivative; structurally, it is a heterocyclic organic complex with many functional groups instead of a straightforward inorganic salt or simple small-molecule solvent.
It may have vasodilatory effects and is a member of the class of phosphodiesterase type 5 inhibitors. Its inhibition of PDE5 enzyme activity and the connection between this inhibition and processes including smooth muscle relaxation, blood flow regulation, and the physiology of penile erection are its main research significance. Its molecular characteristics, chemical structure, and related enzyme inhibition methods serve as a basis for pharmacology, medicinal chemistry, and related experimental investigations. Please get in touch with Xi'an Sonwu if you're interested in dasantafil powder.
Certificate Of Analysis (Tadalafil)
SCH-446132 For Sale
Xi'an Sonwu Biotech Co. Ltd. has more than ten years of industry experience, specializing in producing and selling raw materials. It has established strong and reliable partnerships with countries in America, Asia, Europe and Oceania. Xi'an Sonwu puts product quality first and strives to provide every customer with high-quality services to fully meet their needs.
Every stage of the Xi'an Sonwu production process is tightly regulated, beginning with the meticulous selection of raw materials. Every facet of Xi'an Sonwu's operations, including sample testing, manufacturing technology, material selection, and staff professionalism, reflects the company's strong commitment to product quality. By carefully controlling every aspect and cutting costs without compromising quality, Xi'an Sonwu can guarantee that clients receive goods that are worth their money.
Customers who consistently acknowledge the high caliber of the items give Xi'an Sonwu positive reviews, which makes them proud. Xi'an Sonwu will provide you with samples to test and further demonstrate their confidence in the goods.
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What Is Dasantafil Do
API powder dasantafil is primarily being investigated as a potential treatment for male erectile dysfunction. Its pharmacological action involves the modulation of the cyclic guanosine monophosphate signaling pathway. Under normal physiological conditions, sexual stimulation triggers the release of nitric oxide from nerves and vascular endothelium; NO activates soluble guanylate cyclase, thereby promoting the conversion of guanosine triphosphate into cGMP. Elevated intracellular cGMP levels activate cGMP-dependent protein kinase, which reduces calcium-mediated contractile signaling in smooth muscle cells and promotes the relaxation of smooth muscle in the corpus cavernosum, thereby increasing local blood flow and facilitating the erectile response.
One of the primary physiological functions of PDE5 is to degrade cGMP, converting it into inactive 5′-GMP. As a PDE5 inhibitor, Dasantafil is expected to function by inhibiting the PDE5-mediated degradation of cGMP and prolonging the duration of the associated signaling, thereby enhancing the smooth muscle relaxation response mediated by the NO–cGMP pathway. Its primary pharmacological target is classified in drug databases as PDE5A-referring to both the gene encoding the catalytic subunit of PDE5 and the corresponding enzyme protein.
PDE5 inhibitors drugs
PDE5 (phosphodiesterase type 5) is an enzyme in the human body responsible for breaking down cyclic guanosine monophosphate (cGMP); it plays a crucial role in regulating male erectile function. Its primary function is to regulate intracellular cGMP concentrations, thereby controlling the intensity and duration of signals that trigger smooth muscle relaxation.
1. What is the mechanism of action of PDE5?
During a normal male erection, sexual stimulation triggers the release of nitric oxide (NO) from nerve endings and vascular endothelium. NO activates soluble guanylate cyclase, promoting the intracellular production of cGMP. Subsequently, cGMP activates protein kinase G, which reduces calcium signaling associated with contraction in smooth muscle cells; this leads to the relaxation of smooth muscle in the corpus cavernosum and increased arterial blood flow, thereby facilitating an erection. PDE5 acts oppositely: it hydrolyzes cGMP into inactive 5′-GMP, causing cGMP levels to drop and dampening the signal for smooth muscle relaxation. Therefore, while PDE5 is a key enzyme in the body's regulation of the erectile response, it is not the sole determinant of erectile capability.
2. What is the function of PDE5 inhibitors?
PDE5 inhibitors work by blocking the enzymatic activity of PDE5, thereby slowing the degradation of cGMP and prolonging the signal for smooth muscle relaxation.
Common PDE5 inhibitors include:
Tadalafil, which is used to treat erectile dysfunction and can also address certain symptoms associated with benign prostatic hyperplasia (BPH).
Dasantafil is also classified as a research compound related to PDE5 inhibitors. However, evidence regarding its clinical efficacy and safety is not as robust as that for the approved drugs mentioned above.
3. The relationship between PDE5 and male erectile function
PDE5 is part of the body's normal physiological regulatory mechanism; high PDE5 activity does not necessarily imply the presence of erectile dysfunction. Erectile function is influenced by a multitude of factors, including vascular health, neurological function, hormone levels, psychological state, and medication use. Furthermore, PDE5 inhibitors do not directly increase testosterone levels or libido; their primary role is to enhance cGMP signaling once sexual stimulation has initiated the process.
Dasantafil VS Tadalafil
1. Similarities
Both products are associated with phosphodiesterase type 5 inhibition, with research primarily focused on male erectile dysfunction. They share a core pharmacological mechanism: inhibiting the PDE5-mediated degradation of cyclic guanosine monophosphate, thereby prolonging NO-cGMP signaling, promoting smooth muscle relaxation in the corpus cavernosum, and increasing local blood flow.
2. Differences
The most significant differences lie in clinical evidence and drug development status, rather than in proven differences in potency. Tadalafil is a drug with established clinical trial data and clearly approved indications, whereas Dasantafil is an investigational compound.
Extensive human data exist regarding the efficacy and pharmacokinetics of tadalafil; the drug is approved for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. In contrast, Dasantafil lacks the comprehensive pharmacokinetic and clinical efficacy data required for a direct comparison; therefore, it cannot be scientifically asserted that it is more potent, faster-acting, longer-lasting, or has fewer side effects than tadalafil. Although their mechanisms of action are similar, effective comparison requires specific experimental data on PDE5 inhibitory potency (IC₅₀ or Ki), selectivity for other PDE subtypes, and human absorption and metabolism characteristics.
From a practical therapeutic perspective, tadalafil offers the advantages of robust clinical evidence, clear dosing regimens, and availability via physician prescription for specific indications. In contrast, Dasantafil's value currently lies primarily in drug development and pharmacological research. The fact that Dasantafil is also a PDE5 inhibitor does not make it an equivalent substitute for tadalafil.
Regarding safety, both agents require attention to the risk of hypotension associated with PDE5 inhibitors. Tadalafil is contraindicated for use with nitrates; clinical safety data for Dasantafil are insufficient, and it should not be used experimentally or in combination with tadalafil.
Factory
1. Xi'an Sonwu Biotech Co., Ltd has a factory to produce, manufacture, and store the products, so it has adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is supported, rigorous data support and after-sales service are provided.
Besides guaranteeing the product, the other most important thing is that customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
FAQ
Please note:
Dasantafil falls within the research field of PDE5 inhibitors. Its chemical structure, molecular properties, and associated enzyme inhibition mechanisms provide a foundation for medicinal chemistry, pharmacology, and related experimental studies. However, available public information and specifications for commercial research reagents cannot substitute for comprehensive clinical evidence, nor do they demonstrate the efficacy and safety associated with approved drugs.
If you want to know the API powder dasantafil price, you can contact Xi'an Sonwu. Click the email, and then you get high-quality dasantafil powder.
Email: sales@sonwu.com
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