Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of levamisole hcl in China. We warmly welcome yuo to wholesale bulk levamisole hcl for sale here from our factory. Quality products and reasonable price are available.
Levamisole Powder
Levamisole HCL is a kind of veterinary drug mainly used for the treatment of roundworm, hookworm, pinworm, and strongyloidiasis. It is a white organic compound that acts as an insect-repellent and immunomodulator. It can selectively inhibit succinate dehydrogenase in the worm muscle so that fumarate cannot be reduced to succinate, thereby affecting the metabolism of the worm muscle and reducing energy production. When the worm is in contact with it, it can depolarize the neuromuscular Muscles and undergo continuous contraction to produce a paralyzing effect, which is excreted with the stool. Because the single dose of this product has a relatively high effective rate, it is suitable for group therapy. This product is better than diethylcarbamazine for Bancroft silkworms, Malayan silkworms, Onchocerciasis, and Microfilariae. Although the long-term effect is not as good as that of diethylcarbamazine, the overall effect is relatively good.
As levamisole hydrochloride is effective to use and in high demand, there are more and more levamisole hydrochloride suppliers in the market. If you need this product, you can contact Xi'an Sonwu. Xi'an Sonwu can offer you high quality and the best price.
Certificate of Analysis
Items | Specifications | Testing results |
Assay | 98.5%-101.0% | 99.68% |
Appearance | A white or almost white crystalline powder | Complies |
Appearance of solution | Meets the requirements | Complies |
Ph | 3.0-4.5 | 4.1 |
Specific optical rotation | -128 º(c=5, H2O) | Complies |
Loss on drying | MAX 0.5% | 0.11% |
Sulphated ash | MAX 0.5% | 0.30% |
Heavy metals | MAX 20ppm | Complies |
As | MAX 2ppm | Complies |
Pb | MAX 1ppm | Complies |
Hg | MAX 1ppm | Complies |
Related substances | Any other impurity ≤0.1% Total impurities ≤0.3% | Meets the requirements 0.04% |
Conclusion | Conform with specifications | |
What is Levamisole Used For?
1. Dewormer
The function of pure levamisole is to expel worms from animals to achieve the deworming effect. It is suitable for the treatment of gastrointestinal nematodes, lungworms, and pig kidney worm infections in cattle, sheep, pigs, dogs, and cats. It also has a certain effect on filariasis. . This product has a good effect on adult worms of Haemonchus, Oster, Trichostrongylus, Cooper nematode, Neck nematode, Esophagus esophagus nematode, Chabert nematode, and Viviparous Nematode in cattle and sheep It has poor activity on immature parasites, poor or inaccurate effects on Strongyloides, Trichuris and Trichuris, and is ineffective on lingering larvae of cattle.
2. Immune Enhancers
Levamisole HCL is an ideal nematode drug, and it is also an immune booster. It can improve the level of cyclic guanylate and cellular immunity in lymphocytes so that those with low immunity can be recovered. Levamisole hydrochloride can restore the inhibited cellular immune function to normal and can also enhance the phagocytic function of mononuclear macrophages, especially when such cells are in a state of inhibition. Some studies have shown that the application of levamisole to 6-week-old chicks at a dose of 25 mg/kg can significantly increase the HI antibody titer and improve the immune response to Newcastle disease virus-infected chickens.
What are the Side Effects of Levamisole?
1. In cattle, symptoms of parasympathetic excitation, foaming or salivation appear in the mouth and nose, excitement or trembling, licking of lips, shaking of the head and other adverse reactions. Symptoms generally subside within 2 hours.
2. After administration in sheep, it can cause temporary excitement in some animals, and goats can produce depression, hyperesthesia, and salivation.
3. Pigs can cause salivation or foaming of the mouth and nose.
4. Gastrointestinal disorders such as vomiting, diarrhea, neurotoxic reactions such as panting, shaking his head, anxiety or other behavioral changes, agranulocytosis, pulmonary edema, immune-mediated rashes such as edema, erythema multiforme, epidermal necrosis, and exfoliation, etc. .
5. The cat can see salivation, excitement, mydriasis, and vomiting.
Mechanism of Action of Levamisole Hydrochloride
In terms of deworming, the deworming mechanism of levamisole hydrochloride is to excite the parasympathetic and sympathetic ganglia of sensitive worms, and the general performance is a nicotinic effect. When taking a high concentration of levamisole hydrochloride, it interferes with the sugar metabolism of nematodes by blocking the reduction of fumaric acid and the oxidation of succinic acid, and finally paralyzes the worms and makes the live worms excrete. Oral administration can be absorbed from the gastrointestinal tract and can be distributed throughout the body after absorption. The apparent volume of distribution in pigs is 2.5L/kg, most of which are metabolized in the liver and kidney, the metabolites are mainly excreted in the urine, less than 6% are excreted in the original form, and a small amount is excreted in the feces. The plasma half-lives are 4 to 6 hours for cattle, 3 to 4 hours for sheep, 3.5 to 6.8 hours for pigs, and 1.8 to 4 hours for dogs.
In terms of immunity, levamisole hydrochloride can increase the concentration of serum a2-macroglobulin and enhance the activity of lysozyme. This can inhibit the adhesion of bacteria or viruses to the respiratory tract, directly destroy pathogens, mediate ADCC, etc., and has a very important protective effect on the body. In addition, levamisole can also promote the synthesis and secretion of secretory IgA. IgA plays an important role in the local immunity of the body, such as protecting the mucous membranes of the respiratory tract and digestive tract. Due to the high content of SIgA in exocrine secretion, it is not easy to be destroyed by general proteases, and it plays an immune role in anti-infection.
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Xi'an Sonwu Biotech Co.,Ltd has its own factory, so it has adequate stock. Also,Xi'an Sonwu has clean and tidy producing department with advanced equipment. With the lead of Xi'an Sonwu, researchers are constantly developing new products to meet customer's need. |
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Xi'an Sonwu Biotech Co.,Ltd has advanced test equipment and professional testers, which all show that Xi'an Sonwu aims to supply accurate and effective data and good service. |
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FAQ
(1) It is forbidden for lactating animals.
(2) When animals are extremely weak or have obvious liver and kidney damage, and cattle are stressed due to immunity, dehorning, castration, etc., they should be used with caution or postponed.
(3) Horses and camels are more sensitive, horses should be used with caution, and camels should not be used.
(4) Atropine detoxification and other symptomatic treatment can be used when this product is poisoned.
If you want to buy levamisole HCL or interest in Xi'an Sonwu, or have other questions about the product, do not hesitate to contact Xi'an Sonwu.
Email: sales@sonwu.com
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