Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of 99% triclabendazole powder in China. We warmly welcome yuo to wholesale bulk 99% triclabendazole powder for sale here from our factory. Quality products and reasonable price are available.
Introduction
99% Triclabendazole Powder is a benzmidazole compound commonly used to treat fascioliasis. Triclobendazole is a narrow-spectrum drug with very high specificity for some Fasciola. Similar to other benzimidazole drugs, its mechanism of action is mainly to inhibit microtubule formation. Triclobendazole-sulfoxide is the active metabolite of triclbendazole, and it can not only destroy mature and immature hepatocytes, but also can be highly combined with proteins and play a metabolic role in the liver. After research on some animals, it was found that triclabendazole has a specific anthelmintic effect on Fasciola, and is a new type of imidazole anthelmintic. Xi'an Sonwu also sells Triclabendazole now, if you feel Interested, please feel free to contact Xi'an Sonwu.
COA of Certificate
Principles
The metabolites of triclabendazole, sulfoxide and sulfone, are considered to be the main active substances, but their insecticidal range is narrow, and only flukes have been found to be effective at present. In vitro experiments have shown that both triclabendazole and sulfoxide metabolites can directly penetrate the surface of the fluke and enter the interior of the worm, and the drug can only exert insecticidal activity when the drug accumulates in the worm to a certain extent.
There are two insecticidal mechanisms of sulfoxide metabolites: one is to interfere and inhibit the microscopic structure of the parasite, so that the intracellular GER network is destroyed, the Golgi complex gradually disappears, and the transport of the secretory body to the cortical surface is inhibited. The other is to inhibit the synthesis of proteins in the worm. These two effects are independent of each other and interact with each other. In the early stage of drug action, it mainly acts on microtubules, while in the later stage, it mainly inhibits protein synthesis. Since protein synthesis is closely related to GER and the Golgi complex, the two synergistically exacerbate each other's effects. These effects can lyse the Fasciola hepatica cortex.
What are Flukes?
Trematodes belong to the class Trematodes of the Platyhelminthes phylum. The worms are leaf-shaped or tongue-shaped, flat dorsal and ventral, symmetrical on both sides, with oral suckers and ventral suckers. Except for schistosomiasis, all are hermaphrodites. The species of flukes are all parasitic, a few are parasitic outside the camp, and most of them live inside the camp. As flukes adapt to parasitic life, a series of changes have taken place in their morphological structure and physiology accordingly. The characteristics of parasitic life are: the environment is relatively stable, limited, and rich in nutrients. In order to adapt to this kind of environment, its motor function degenerates, the body surface has no cilia, no rods, and no general epithelial cells, while most species develop cortex with small spines; nerves and sensory organs also tend to degenerate. The vast majority of flukes are the pathogens of parasitic diseases of various vertebrates, and mollusks and other mollusks are parasitized by the larval stage of flukes and are also damaged. Therefore, people and animals of all kinds can be harmed to varying degrees.
Functions
99% Triclabendazole Powder is a new type of imidazole anthelmintic drug, which has a very significant anthelmintic effect. Many experiments have shown that the veterinary drug triclabendazole has a certain killing effect on the larvae and adults of Fasciola hepatica. It has been reported that after taking the product at 5 mg/kg to sheep, the larvae reduction rate is 87%, and it also has a good killing effect on adults; the killing rate of 10 mg/kg on the adult and larvae of Fasciola hepatica is as high as 99%. %; Goat 5 mg/kg and calf 6 mg/kg have 100% killing effect on Fasciola hepatica adults; horse 12 mg/kg can completely kill Fasciola hepatica adults and larvae, these reports are all trichloride A manifestation of the obvious anthelmintic effect of bendazole.
Side Effects
1. Triclobendazole has a slight irritating effect on rabbit skin, but it is not irritating to rabbit eyes.
2. After 13 weeks of feeding triclobendazole and chow to rats, it was found that there were no side effects after eating low doses, and weight loss, hemoglobin decreased, plasma enzymes and cholesterol levels increased in medium and high doses.
Other side effects of 99%Triclabendazole Powder have not been confirmed by research. Seek advice from your veterinarian before giving to animals in your home and use the dosage recommended by your veterinarian.
Instructions
Triclobendazole as a novel imidazole anthelmintic. It is available in two forms: powder and tablet. Xi'an Sonwu offers veterinary grade powder. It can be taken orally with feed, once a day.
Here are some recommended doses:
Sheep and cattle: 10 mg/kg;
For deer: 10 mg/kg;
Horses: 12 mg/kg.
In addition, triclobendazole can be taken alone or in combination with levamisole and pyroantel, both of which will have a deworming effect.
FAQ
1. How to buy products from Xi'an Sonwu?
You can contact Xi'an Sonwu via email, phone, and social media.
2.How to ensure the product quality before ordering?
Each batch of products needs to be tested to provide customers with COA and other third parties.
3. How to pack and store 99% Triclabendazole Powder?
Packaging: export grade sealed drum, vacuum sealed aluminum foil packaging, can also be packed according to customer needs.
Storage: please store in a cool and dry place to avoid bright light and high temperature.
If you want ot buy Triclabendazole Powder, feel free to contact Xi'an Sonwu.
E-mail: sales@sonwu.com
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