Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of 99 powder itraconazole in China. We warmly welcome yuo to wholesale bulk 99 powder itraconazole for sale here from our factory. Quality products and reasonable price are available.
What Type Of Drug Is Itraconazole
99 powder itraconazole is a synthetic broad-spectrum antifungal drug, a triazole derivative. It is effective against dermatophytes (Trichophyton, Microsporum, Epidermophyton floccosum), yeasts [Cryptococcus neoformans, Pityrosporum, Candida (including Candida albicans, Candida glabrata and Candida krusei)], Aspergillus, Histoplasma, Paracoccidioides brasiliensis, Sporothrix schenckii, Chromatids, Cladosporium, Blastomyces dermatitidis and various other yeast and fungal infections. It can be converted into inactive metabolites in the liver and then excreted from the body through bile and urine. In vitro studies have shown that it can inhibit the synthesis of ergosterol, one of the main components of fungal cell membranes, thereby exerting an antifungal effect. Its antibacterial spectrum is similar to that of fluconazole, and it has significant antibacterial activity against both deep and superficial fungi. Its wide application makes it an essential drug for treating various fungal infections, especially some refractory and systemic fungal infections. Due to its wide range of effects, it treats existing infections and prevents possible fungal infections. Its application range covers a variety of infections from the skin surface to deep tissues and organs, making it an essential player in the field of antifungal therapy. So, if you need raw itraconazole materials, Xi'an sonwu can provide them.
Certificate Of Analysis
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Items |
Specifications |
Results |
|
Appearance |
White or almost white powder |
Almost white powder |
|
Identification |
IR conforms to standard(2.2.24) |
Complies |
|
Appearance of solution |
Solution S is clear(2.2.1) and not more intensely colored than |
Complies |
|
Related substances |
(2.2.29) |
|
|
Impurities B |
Not more than 0.3% |
Not detected |
|
Impurities G |
Not more than 0.3% |
0.1% |
|
Impurity E |
Not more than 0.2% |
Not detected |
|
Sum of impurities C and D |
Not more than 0.3% |
Not detected |
|
Unspecified impurities |
Not more than 0.10% |
0.06% |
|
Total impurities |
Not more than 0.8% |
0.3% |
|
Loss on drying |
Not more than 0.5% |
0.1% |
|
Sulfated ash |
Not more than 0.10% |
0.03% |
|
Assay |
99.0% to 101.0% |
99.7% |
Buy Itraconazole Online
With over a decade of experience in the business, Xi'an Sonwu Biotech Co. Ltd. is an expert in the production and distribution of raw materials. Xi'an Sonwu has formed solid and dependable alliances with nations in America, Asia, Europe, and Oceania. Prioritizing product quality, Xi'an Sonwu works hard to satisfy each client's expectations in full by offering top-notch services.
Xi'an Sonwu prioritizes producing high-quality goods, and all facets of its business operations, such as raw material selection, manufacturing procedures, sample testing, and staff professionalism, reflect the company's commitment to excellence. Xi'an Sonwu may reduce expenses without sacrificing quality by carefully monitoring every detail, guaranteeing that clients receive items of remarkable value.
Xi'an Sonwu is pleased with the favorable comments it has gotten from clients who have continuously acknowledged the high caliber of the offerings. Xi'an Sonwu will provide samples for you to test to demonstrate product confidence further.
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Form |
Sample Amount |
MOQ |
|
Powder |
100g |
100g |
Customers' Good Comment
Is Itraconazole Stronger Than Fluconazole
They are both broad-spectrum antifungal drugs belonging to the triazole antifungal drugs, but their mechanism of action, application range, drug properties, and side effects are different.
1. Mechanism of action
It inhibits the synthesis of ergosterol in the fungal cell membrane, interferes with the structure and function of the fungal cell membrane, and ultimately leads to fungal cell death. It has a broad-spectrum inhibitory effect on a variety of fungi. Fluconazole also exerts its antifungal effect by inhibiting the synthesis of ergosterol. Still, its main target is Candida and some other types of fungi, and its spectrum of action is relatively narrow.
2. Antifungal spectrum
99 powder itraconazole is effective against various fungi such as dermatophytes, Candida, Cryptococcus, Aspergillus, Histoplasma, Blastomyces, and pigmented fungi. It has a good effect on many infections, including systemic fungal infections. Fluconazole is effective against Candida, Cryptococcus, and some dermatophytes but is less effective against less common fungal infections such as Aspergillus, Histoplasma, and Blastomyces. In addition, fluconazole is ineffective against some Candida (such as Candida krusei) and has poor effects on other resistant Candida (such as Candida glabrata).
3. Clinical application
It is used to treat dermatophytosis (such as tinea manuum, tinea corporis, tinea cruris), onychomycosis, systemic fungal infections (such as histoplasmosis, blastomycosis, cryptococcosis), sporotrichosis and chromomycosis. It is suitable for Candida infections and is resistant to fluconazole. Additionally, it acts as a prophylactic strategy against fungal infections for people with compromised immune systems. Treatments for dermatophyte infections, cryptococcal meningitis, and Candida infections (including vaginal, esophageal, and oral candidiasis) commonly involve the use of fluconazole. In AIDS patients, fluconazole is often used to prevent cryptococcal infections.
4. Pharmacokinetics
It is widely distributed in the body, especially in the stratum corneum, nails, hair follicles, and other parts with high concentrations, so it has significant therapeutic effects on onychomycosis and dermatophytosis. Fluconazole is well absorbed orally, has high bioavailability, and is not affected by food, usually more than 90%. Fluconazole has stable blood concentrations and good permeability, especially in the central nervous system (CNS), where it reaches effective concentrations, so it is often used to treat cryptococcal meningitis.
What Is Itraconazole Used To Treat
1. Dermatophyte Infections
Tinea corporis
Fungal infection of a body part, commonly known as "ringworm."
Tinea pedis
Fungal infection of the foot is sometimes called "athlete's foot" or "tinea pedis."
Tinea cruris
Fungal infection of the thighs (inner thighs), often known as "jock itch."
Tinea capitis
Fungal infection of the scalp, usually in children.
Tinea unguium / Onychomycosis
Fingernail or toenail fungus infections result in thicker, discolored, and malformed nails.
2. Candidiasis
Oropharyngeal candidiasis
Candida infection of the mouth and pharynx, commonly known as "thrush."
Esophageal candidiasis
A more severe Candida infection that affects the esophagus.
Vulvovaginal candidiasis
A candidal infection of the vaginal area of women is usually characterized by itching, burning, and discharge.
Chronic mucocutaneous candidiasis
It is a rare disease that causes persistent candidal infection of the skin, nails, and mucous membranes.
3. Systemic fungal infections
Histoplasmosis
Caused by inhalation of Histoplasma capsulatum spores, it primarily affects the lungs.
Blastomycosis
Blastomyces dermatitidis usually affects the lungs but can also affect other organs.
Aspergillosis
Caused by Aspergillus spp., it often affects the lungs, especially in immunocompromised patients.
Cryptococcosis
Caused by Cryptococcus neoformans, it usually affects the lungs and central nervous system.
4. Sporotrichosis
A long-term fungal infection mainly affects the skin and underlying tissue and is brought on by Sporothrix schenckii.
5. Paracoccidioidomycosis
Though it can spread to other body parts, this fungal illness is mainly caused by Paracoccidioides and affects the lungs.
6. Coccidioidomycosis
Also known as "Valley Fever," Coccidioides spp. It causes it and usually affects the lungs but can cause systemic illness.
7. Chromoblastomycosis
A chronic skin infection caused by a specific type of fungus that causes scaly, wart-like lesions on the skin.
8. Preventive treatment for immunocompromised patients
When treating immunocompromised patients (such as those receiving organ transplants or chemotherapy), it is occasionally administered to prevent fungal infections.
9. Allergic fungal infections
Itraconazole may also treat allergic bronchopulmonary aspergillosis (ABPA), an immune system response caused by a lung fungal infection.
Itraconazole How Does It Work
As a triazole antifungal drug, it inhibits the growth and reproduction of fungi through specific molecular targets and mechanisms of action. Fungi cannot survive without their cell membranes' proper structure and functionality. Unlike human cell membranes, which mainly contain cholesterol, the main component of fungal cell membranes is ergosterol. Ergosterol is critical in maintaining membrane structure, fluidity, and function in fungal cell membranes. If the synthesis of ergosterol is disturbed, the integrity of the fungal cell membrane will be destroyed, eventually leading to cell death. Therefore, drugs targeting the ergosterol synthesis pathway, such as itraconazole, play an essential role in antifungal treatment.
It primarily targets 14-α-demethylase, an essential enzyme in the route leading to ergosterol production. 14-α-demethylase is part of the cytochrome P450 enzyme family. It is responsible for catalyzing the removal of the methyl group at the 14th position of lanosterol to generate intermediates that are further converted into ergosterol. If this process is inhibited, lanosterol will not be converted into ergosterol but accumulate in the cell. Lanosterol and its intermediates that fail to complete the conversion occupy positions in the cell membrane, disrupting the structure and function of the membrane. This inhibition prevents the demethylation reaction of lanosterol, thereby blocking the ergosterol synthesis pathway. Due to the lack of ergosterol, the structure of the fungal cell membrane becomes unstable. This structural instability makes the cell membrane more permeable, destroying its barrier function to the internal and external environment of the cell and ultimately leading to cell death.
Factory
1. Xi'an Sonwu Biotech Co., Ltd. possesses a factory for producing, manufacturing, and storing its products, ensuring a sufficient inventory. Xi'an Sonwu's production section is neat, orderly, and well-kept. Researchers can consistently produce novel, high-quality items under Xi'an Sonwu.
2. Xi'an Sonwu has stringent guidelines about staffing levels, ranging from sales and testing to production and testing. Entire product escorting is guaranteed by strict data support and after-sale services.
Certificates
Packaging
Logistics
Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
FAQ
1. Strong Strength
Xi'an Sonwu's own producing workshop is an OEM factory and lab.
2. Experienced
Doing export business all over the world for more than ten years.
3. Professional team
Xi'an Sonwu has a perfect R& sales and service team.
4. Sincere Service
Xi'an Sonwu has a perfect R& sales and service team. Xi'an Sonwu Having been in the industry for many years, the customer praise rate has reached 99%.
5. Customers' review
Xi'an Sonwu Having been in the industry for many years, the customer praise rate has reached 99%.
If you want to know itraconazole materials price, you can contact Xi'an Sonwu. Click the email, and then you get high-quality 99 powder itraconazole.
Email: sales@sonwu.com
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