Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of pure piperine in China. We warmly welcome yuo to wholesale bulk pure piperine for sale here from our factory. Quality products and reasonable price are available.
What Is Piperine?
Pure piperine, also called piperin and bioperine, is an alkaloid extracted from black pepper. Black pepper is a tropical woody vine of Magnolia in Piperaceae. It is known as the "King of Spices" and "Black Gold". Piperin is an alkaloid extracted from black pepper and used to increase the bioavailability and metabolism of nootropic supplements and medicines. The extract makes nootropics more bioavailable by inhibiting the activity of the medicine transporter p-glycoprotein and the major medicine metabolizing enzyme CYP3A4 in the liver. And piperin extracted from black pepper is very helpful to human body.
From the perspective of human history and civilization, piperine occupies a unique position. In medieval Europe, pepper was a symbol of social status and wealth. It was worth more than gold and silver, and could be used as currency. So, the expansion of the pepper trade route has contributed to important historical events, such as the opening of new shipping routes and great geographic discoveries. Currently, black pepper is widely planted in more than 30 tropical and subtropical countries, and has obtained great popularity in the market for its multiple use. As a professional piperine manufacturer, Xi'an Sonwu can supply high quality products with competitive price. If you're interested in, please feel free to contact Xi'an Sonwu.
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How Does Piperine Work in the Brain?
Pure piperine may benefit cognitive function in the brain. According to animal studies, black pepper extract can significantly improve memory in mice with Alzheimer's disease, possibly because it reduces oxidative stress in the brain region of the hippocampus. It can boost brain health and function in several ways. But there are three main point.
1. It is an anti-depressant.
Piperine is similar to monoamine oxidase inhibitor (MAOI), and can inhibit both MAO-A and MAO-B. Research has found that piperine is as effective as antidepressant fluoxetine. At the same time, it was founded that piperin significantly increases serotonin (5-HT) in the hippocampus and frontal cortex. Piperine may provide antidepressant effects as an MAOI inhibitor and serotonin potentiator.
According to the study, combining piperin with resveratrol can provide significant antidepressant effects. Resveratrol itself is a good antidepressant. When used in combination, it not only provides antidepressant effects but also increases resveratrol bioavailability. This combination is an effective natural antidepressant. This stacked use relieves oxidative stress, inflammation, and provides neuroprotection without other side effects.
2. It can boost bioavailability.
Piperine can improve bioavailability by combing with other extracts.
A good example is curcumin. Curcumin is an all-natural compound derived from the root of turmeric. It is the most active constituent of the polyphenolic curcuminoids and has good anti-inflammatory properties. But the bioavailability of curcumin when taken as a supplement is very poor because it is rapidly metabolized in the liver and intestinal lining. Users will not experience the medicinal properties of curcumin when taken alone.
According to the study, the researchers gave mice 2 g/kg of curcumin and tested blood levels over 4 hours. The result is very small amounts of curcumin were detected in the blood. While then they gave the mice equal amounts of curcumin and 20 mg/kg of piperin. With the addition of it, blood levels of curcumin were detected quickly and stayed in the blood longer. The study found that the bioavailability of curcumin in mice increased by 154% when combined with piperin.
The researchers then conducted experiments on humans. Taking 2 grams of curcumin alone was undetectable in blood samples in two hours. However, taking 2 grams of curcumin and 20 mg of piperin at the same time showed up in a blood sample within 15 minutes. It was concluded that piperin increased the bioavailability of curcumin by 2000%.
3. It can protect against Alzheimer's.
A study in Thailand examined the effects of piperine on memory and neurodegeneration in Alzheimer's disease.The scientists administered piperin at doses of 5 mg/kg, 10 mg/kg and 20 mg/kg for the first 2 weeks and 1 week after artificially induced Alzheimer's disease-like conditions in the rat brains.
The results showed that it significantly improved memory impairment and neurodegeneration in mice at all dose ranges.Scientists speculate that piperin may be responsible for these effects by reducing lipid peroxidation and acetylcholinesterase. Acetylcholinesterase is a key enzyme in biological nerve conduction. It can degrade acetylcholine between choline and synapse, and terminate the excitatory effect of neurotransmitter on the post-synaptic membrane, thereby ensuring the normal transmission of nerve signals.
Dosage Notes
There are various recommendations for dosing. In the market, many nootropics and some supplement formulas come pre-stacked with the appropriate dose of piperine, such as curcumin and resveratrol. The recommended dosage of piperine to enhance bioavailability of nootropic supplements is 5mg to 20 mg per day.
In short, please consult your doctor before taking it.
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Side Effects
Piperin, an extract of black pepper, is considered nontoxic and safe at recommended doses. Piperine enhances the effects of almost all nootropic supplements and prescription medicines. So be aware that the effects of mixing with certain supplements or medications may have adverse consequences. If you add it to your daily use for the first time, please conduct a low-dose independent test or use it under the guidance of a doctor to avoid unnecessary effects on your body.
Piperin Precautions & Interactions
1. Avoiding piperine if you are pregnant;
2. Excessive long-term use can cause gastrointestinal inflammatory reactions such as abdominal pain.
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Why Choose Us?
Pre-Sales service：
1. OEM service;
2. Supporting sample testing;
3. Each batch of products is tested to ensure quality;
4. Product packaging can be customized according to customer requirements;
5. Inquiry will be replied within 24 hours to provide customers with customized products and services;
6. Providing commercial invoice, packing list, bill of lading, COA and other supporting documents. If the market has special requirements, please let us know in time.
After-Sales service:
1. Real-time update of logistics information;
2. Any products with quality problem can be returned;
3. Any questions about products can be consulted at any time.
If you need to buy pure piperine, you can contact Xi'an Sonwu directly.
E-mail: sales@sonwu.com
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