Picropodophyllotoxin Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of picropodophyllotoxin powder in China. We warmly welcome yuo to wholesale bulk picropodophyllotoxin powder for sale here from our factory. Quality products and reasonable price are available.

CAS 477 47 4 IGF 1R
Picropodophyllotoxin powder is a compound with Chemical Abstracts Service (CAS) registration number 477 47 4 and a complex insulin-like growth factor 1 receptor (IGF-1R). A receptor protein called IGF-1R is essential for cell survival, growth, and division. Because they play a part in encouraging the development of dead cells and resistance to particular treatments, sick cell populations are the focus of its research.
It also goes by PPT and is a lignan, chemically speaking. It has gained interest for its possible medical uses. Numerous species of Podophyllum sinensis, Aniseliana, and Podophyllum are among the plants that contain it. Due to their potential as medicines, podophyllotoxins have drawn much attention in scientific studies. Studies suggest that by boosting cell death and reducing the formation of sick cells, it may have anti-major illness properties. Leukemia, breast, lung, and colon issues are a few cellular disorders studied using this method. Due to their potential characteristics, podophyllotoxins have attracted attention in therapeutic research. Its prospective applications are being investigated, its structural flaws are being fixed, and efforts are being made to develop analogs that are more toxic-free and powerful while also being more effective. Xi'an Sonwu can provide you with pure picropodophyllotoxin; if you are interested in lignan products, you can contact Xi'an Sonwu anytime.

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CAS 477 47 4 Powder For Sale

With more than a decade of expertise in the market and a focus on producing and distributing raw materials, Xi'an Sonwu Biotech Co. Ltd. Xi'an Sonwu has stable and trustworthy alliances with nations in North America, South America, Asia, Europe, and Oceania. Xi'an Sonwu puts product quality first and strives to provide every customer with high-quality services to meet their needs fully.
For Xi'an Sonwu, producing high-quality products is a top concern. This dedication to excellence is evident in all parts of the business, including material choice, production processes, sample testing, and staff professionalism. To cut expenses without sacrificing quality and guarantee that clients obtain items of excellent value, Xi'an Sonwu painstakingly manages every element.
Xi'an Sonwu is proud of the positive feedback it has received from customers, who have consistently recognized the quality of the products. To further prove product confidence, Xi'an Sonwu will provide samples for you to test.

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What Is The Mode Of Action Of Podophyllum

Picropodophyllotoxin powder mode of action and targets of it are still being investigated, and there is limited information on its specific molecular targets. But, according to recent studies, it is thought to interact with several cellular targets, which may be a factor in its potential therapeutic effects.

Inhibition of DNA Topoisomerase II: It interacts with DNA Topoisomerase II, a crucial enzyme in DNA replication and repair, and prevents it from functioning. By inhibiting this enzyme, it disrupts the normal function of topoisomerase II in managing DNA structure and integrity.

DNA Damage and Cell Cycle Arrest: The inhibition of topoisomerase II by it leads to stable ternary complexes between the drug, topoisomerase II, and DNA. DNA damage caused by these complexes includes DNA strand breakage and DNA-protein crosslinks. DNA damage builds up and causes cell division to stop, arresting the cell cycle.
Disruption of Microtubule Formation: The crucial cellular components known as microtubules play a role in many cellular functions, including cell division. When microtubules malfunction during cell division, podophyllotoxins cause havoc with chromosome segregation. By inhibiting this process, podophyllotoxins prevent cell division and proliferation, ultimately inhibiting diseased-cell growth.

In addition to its effects on microtubules, it has modulated various signaling pathways involved in cell survival and apoptosis (programmed cell death). These pathways are governed, among other proteins, by Bcl-2, caspases, and p53. It can trigger apoptosis in sick cells and threaten survival by interfering with these processes.

Antioxidant properties of it have been discovered, which may help to explain its potential effects. It may lessen cell damage and enhance their general health by lowering oxidative stress.

CAS 477 47 4 Effect IGF 1R

1. Anti-inflammatory effects
Inflammation is the body's natural response to an injury. But, chronic inflammation has been linked to the onset and progression of illnesses like diseased cells, diabetes, and cardiovascular conditions. According to preliminary research, it may have anti-inflammatory advantages by blocking the production of pro-inflammatory molecules.

2. Antioxidant properties
When the body's capacity to detoxify reactive oxygen species (ROS) and their creation are out of balance, oxidative stress results. Numerous diseases, such as diseased cells, neurological conditions, and cardiovascular ailments, are influenced by oxidative stress. Antioxidant qualities have been discovered in it, which may help lower oxidative stress and shield cells from ROS-related cell damage.

3. Antimicrobial activity
It may have antibacterial properties, according to several investigations. It has demonstrated activity against various diseases, including fungi and bacteria. It may prevent the growth of these bacteria by obstructing crucial biological functions like DNA replication and cell division.

4. Neuroprotective effects
Both Alzheimer's disease and Parkinson's disease are neurodegenerative illnesses that gradually destroy brain neurons. It has demonstrated promising outcomes in early research as a potential neuroprotective drug. It may reduce inflammatory brain conditions, protect neurons from oxidative damage, and increase cellular viability.
5. Antiviral effects
It may have antiviral capabilities, according to some investigations. Numerous viruses, including respiratory syncytial viruses and herpes simplex, are inhibited by it. The specific mechanisms by which it exerts its antiviral effects are still being researched.
 

CAS 477 47 4 Side Effects Long Term

Gastrointestinal disturbances: Using organic substances with cytotoxic effects, such as picropodophyllotoxin, can occasionally cause gastrointestinal problems like nausea, vomiting, or diarrhea. If these side effects occur, looking for a doctor is essential.

Allergic reactions: Some individuals can be allergic toit, as with any other substance. There will be itching, rash, swelling, or difficulty breathing. If you experience any of these symptoms after using it, it is vital to seek medical attention immediately.

Interactions with medications or other substances: It may interact with certain medications or substances. Suppose you are taking any medications or have any underlying health conditions. In that case, it is essential to consult with a healthcare professional or medical expert before using it to avoid any potential interactions.

Factory
1. Xi'an Sonwu Biotech Co., Ltd has a factory to produce, manufacture, and store the products, so it has adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.

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Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ
It should be noted that there is also a lignan product called podophyllotoxin and picropodophyllotoxin, and it is two different compounds; podophyllotoxin is a natural compound usually extracted from plants such as Mayapple (Podophyllum peltatum). But, picropodophyllotoxin was discovered in the Podophyllum hexandrum plant.
If you want to know the picropodophyllotoxin extract powder manufacturer, you can contact Xi'an Sonwu. Click the email, and then you get high-quality picropodophyllotoxin powder.
Email: sales@sonwu.com

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