Lumbrokinase Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of lumbrokinase powder in China. We warmly welcome yuo to wholesale bulk lumbrokinase powder for sale here from our factory. Quality products and reasonable price are available.

Lumbrokinase Supplement

Lumbrokinase powder, also known as Bolucke, is a group of proteolytic enzymes with complete lumbrokinase extracted directly from earthworms, with a molecular weight of 16,000-45,000 D. Lumbrokinase can now degrade fibrin in the blood under physiological conditions and activate plasminogen into plasmin to accelerate the dissolution of thrombus. Therefore, lumbrokinase can also be used as an antithrombotic drug, and it is mainly used clinically for thrombotic diseases, especially for patients with increased fibrinogen and increased platelet aggregation rate. It can improve symptoms and prevent disease progression for ischemic cardiovascular and cerebrovascular diseases. Animal experiments also inhibit platelet adhesion, degrading fibrinogen, prothrombin, and FⅧ. Lumbrokinase can reduce the content of fibrinogen, shorten the dissolution time of euglobulin, and reduce the viscosity of whole blood and plasma. In addition, it can also increase t-PA activity, reduce plasminogen activator inhibitory activity, improve fibrin degradation products, etc.

Lumbrokinase has been proven to have good clinical application value and is a multi-molecular recombinant oral preparation. It has a particular affinity for thrombus, can track thrombolysis, effectively dissolve microemboli, and improve microcirculation. It can also strengthen the collateral circulation of heart and brain vessels, openly repair damaged endothelial cells of blood vessels, increase the elasticity of blood vessels, improve the oxygen supply function of blood vessels, reduce blood viscosity, and reduce the rate of platelet aggregation, thereby inhibiting the formation of thrombus again. Repair peripheral necrotic brain cells after thrombosis, and save the penumbra. It has been widely used clinically and is increasingly used in the prevention and treatment centers of heart, cerebrovascular, endocrine, respiratory system, and other diseases. So there are more and more lumbrokinase manufacturers in the market. If you want the best quality products at the best price, you can find the supplier Xi'an Sonwu.

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Where To Buy Lumbrokinase

Xi'an Sonwu Biotech Co. ltd. has more than ten years of experience in the global trade and health industry. Adhere to the principle of product quality first. Xi'an Sonwu strictly controls product quality, which means selection starts from raw materials. Besides, Xi'an Sonwu handles every detail and reduces the cost to the maximum extent so that customers can get a cost-effective product. Based on these, customers have given much good feedback to products. So look for Xi'an Sonwu Biotech Co. ltd. when buying lumbrokinase.

Xi'an Sonwu fails to ensure the product's quality and provides the samples. Here is the quantity.

Customers' Good Comment

OEM Service

Xi'an Sonwu can supply high-quality Bolucke powder and Bolucke capsules.

So any customers could customize the capsules they want. And customers can decide on the following items.

1. Customized capsules shells (size, color, material)

2. Customized bottles(size, color, material, style)

3. Customized packaging(vacuum foil packaging, box, drum)

4. Customized label(paint film, matte film, optical mask)

What Is Lumbrokinase Used For

1. Coronary heart disease

PAI and t-PA are mainly a pair of biological regulators synthesized and secreted by vascular endothelial cells, which are of great significance to the function of the fibrinolytic system. T-PA can specifically bind to fibrin in thrombus and has a selective thrombolytic effect. PAI is a rapid inhibitor that can irreversibly combine with t-PA and lumbrokinase to inactivate it and inhibit the function of lumbrokinase, which plays a decisive role in regulating the fibrinolytic system. Lumbrokinase can increase the activity of PAI in patients with coronary heart disease and inhibit the activity of t-PA, resulting in low fibrinolysis. Lumbrokinase powder mainly activates plasminogen in plasma to convert it into plasmin with thrombolytic activity, degrading fibrinogen and fibrin clots and melting the thrombus.

Studies have shown that the plasma t-PA activity of patients in the acute myocardial infarction group was significantly increased after being treated for 12 hours according to the usual treatment method. On the third day, the difference was still significant compared with that before treatment, and it was not until the seventh day that it gradually returned to the original level. After five days of treatment with lumbrokinase, it can significantly improve the function of the fibrinolytic system.

2. Cerebral infarction

Cerebral infarction is the most common cerebrovascular disease, accounting for about 50% to 60% of cerebrovascular diseases. In the acute stage of cerebral infarction, measures such as controlling cerebral edema, increasing cerebral blood flow, and oxygen saturation of cerebral tissue are beneficial to patients. Clinical observations showed that 665 patients with cerebral infarction were treated with lumbrokinase capsules orally for 15-28 days, the effective rate was 60.94%-73.66%, and the total effective rate was 88.0%-98.88%. 98.6% of patients had significantly reduced embolism volume, and the average embolism volume reduction rate was 74.1%. The improvement rate of crooked mouth, eyes, and limb numbness after taking medicine for 3-5 days accounted for 79.85%. After treatment, the improvement rate for patients with dizziness and headache was 95.95%. The improvement rate of tongue stiffness was 94.7%, mouth and eye crookedness was 91.3%, hemiplegia was 92.3%, limb numbness was 92.9%, and hand and foot urgency was 85.7%.

Clinical studies have confirmed that lumbrokinase has a particular affinity with fibrin. It does not affect the body's normal blood coagulation system function but can significantly reduce the scope of the ischemic penumbra. The use of lumbrokinase in the treatment of cerebral infarction has a significant effect on the recovery of paralyzed limbs, can effectively improve the clinical symptoms and signs of patients with cerebral infarction, reduce the disability rate of patients, and have mild sequelae. Compared with the usual therapeutic drugs, Lumbrokinase has significantly higher marked and effective rates than Venus antithrombotic enzyme and Xueshuan Xinmaining, and the recurrence rate is considerably lower than typical aspirin therapy and ticlopidine hydrochloride and other drugs, with mild side effects. Lumbrokinase is an ideal drug for the prevention and treatment of cerebral infarction.

3. Diabetes

Increased platelet adhesion and aggregation function are one of the reasons why diabetic patients have an early and high incidence of arteriosclerosis and are prone to complicate microvascular diseases. Lumbrokinase is a group of acidic proteins extracted from artificially reared Eisenia earthworms. Plasma TXB2 levels in diabetic patients decreased significantly after the oral administration of lumbrokinase for two weeks. There was no significant difference with the control group, suggesting that lumbrokinase significantly inhibited platelet adhesion and aggregation. Plasma GMP140 levels also decreased significantly after treatment, indicating that lumbrokinase can inhibit platelet activation in diabetic patients to a certain extent.

4. Pulmonary heart disease

The clinical research of lumbrokinase on cor pulmonale confirmed that the hemorheological indexes of the patients changed significantly, the clinical symptoms improved, and the total effective rate of treatment was 88.4%. The nail fold microcirculation examination of the patient showed that the red blood cell aggregation and dark red blood that was found before treatment were improved, the oxygen content in the patient's body increased, chest tightness and shortness of breath, cyanosis symptoms were alleviated, and no adverse reactions occurred. It is a safe and effective anti-thrombolytic drug for treating pulmonary heart disease,

lower extremity deep vein thrombosis.

Lumbrokinase Mechanism Of Action

At present, its mechanism of action has been confirmed. First, it functions as a plasminogen activator; second, it combines with fibrin to rapidly degrade fibrin. These two mechanisms have direct and indirect thrombolytic parts. That is to say, and lumbrokinase can smoothly enter the microvessels through a variety of active enzyme small molecules, dissolve the microemboli in the microvessels, restore the elasticity of the microvessels, and thereby relieve the blockage of the micro. The old thrombus in the capillaries, after unblocking is cleared, can improve the body's anticoagulant function and activate the differentiation characteristics of vascular endothelial cells. Thereby promoting microvascular regeneration, establishing collateral circulation, opening up new blood pathways for the heart and brain tissue in the lesion area, and repairing necrotic brain nerve cells.

It is an enzyme complex with a fibrinolytic effect, which can directly hydrolyze fibrinogen, produce soluble fibrinogen degradation products, reduce the content of fibrinogen, and prevent thrombosis. Lumbrokinase contains the components of plasminogen activator and plasmin, which can promote the conversion of plasminogen into plasmin. Degradation of insoluble fibrin can dissolve the blood test of early cerebral infarction. Lumbrokinase has t-PA-like activity and selectively promotes fibrinolytic activity.

Lumbrokinase Side Effects

1. Digestive tract: Lumbrokinase is a proteolytic enzyme isolated from earthworms. It belongs to antithrombotic drugs and treats ischemic cerebrovascular diseases with increased fibrinogen or platelet aggregation rate. Gastrointestinal symptoms include nausea, vomiting, and gastrointestinal discomfort, so take medicine before meals.

2. Nervous system: General side effects include allergic reactions such as rash and itching, dizziness, headache, and other symptoms may also occur. It is recommended that lumbrokinase should be used under the guidance of a doctor. Lumbrokinase should be avoided in combination with other medications as an antithrombotic drug.

Use caution in patients with acute bleeding and those with a bleeding tendency. Because lumbrokinase is an enzyme complex with a fibrinolytic effect, it can reduce fibrinogen's content and the concentration of plasminogen activator. Inhibitory activity can also reduce whole blood viscosity and plasma viscosity. Therefore, lumbrokinase is mainly suitable for patients with an ischemic cerebrovascular disease with increased fibrinogen and platelet aggregation rate.

Factory

1. Xi'an Sonwu Biotech Co., Ltd has adequate stock due to it has own factory to produce, manufacture and store the products. Xi'an Sonwu has a transparent system and strict process production and testing department. Under Xi'an Sonwu, researchers can keep producing high-quality and best-price products.

2. Xi'an Sonwu has high requirements for every factory personnel, whether in production, testing, or sales. Ensure every product sold is of high quality and every service is satisfactory to customers.

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Logistics

Xi'an Sonwu, besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ

The daily dose of lumbrokinase is usually about 200 mg. People who take lumbrokinase capsules must be taken half an hour before meals. Suppose elderly patients want to avoid drug overdose. In that case, they need to use the drug at a regular dose, mainly because the tolerance of this drug is relatively good, and the properties of this drug are similar to those of drugs that inhibit platelet function.

If you want to know the lumbrokinase price, you can contact Xi'an Sonwu. Click the email then you get high-quality lumbrokinase powder.

Email:sales@sonwu.com

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