Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of ll-37 powder in China. We warmly welcome yuo to wholesale bulk ll-37 powder for sale here from our factory. Quality products and reasonable price are available.
What Is LL-37
LL-37 Powder is a human antimicrobial peptide derived from the human cationic antimicrobial protein 18, also known as cathelicidin. Short chains of amino acids known as antimicrobial peptides are essential components of the innate immune system, serving as a first line of defense against various pathogens, including bacteria, viruses, and fungi. In the case of LL-37, it is produced by cleaving a specific portion of the hCAP18 protein. It has antimicrobial properties, meaning it can directly kill or inhibit the growth of microbes. It is a cationic peptide, meaning it carries a positive charge, which empowers it to connect with and disrupt the negatively charged membranes of microorganisms.
It is produced by various cell types, including white blood cells (neutrophils and macrophages) and epithelial cells. It assumes an essential part in the body's safeguard against infections and contributes to the overall immune response. Notwithstanding its antimicrobial properties, LL-37 has been studied for its roles in wound healing, immunomodulation, and anti-inflammatory processes. Research is ongoing to understand the full range of LL-37's functions and explore its potential applications in medicine, such as in the development of novel antimicrobial therapies or treatments for conditions involving inflammation and tissue repair.
Structure and Source
LL-37 is a cationic (positively charged) α-helical peptide with 37 amino acids.
It is derived from the C-terminal region of human cathelicidin (hCAP18).
Primarily produced by neutrophils, epithelial cells, and macrophages in response to infection or inflammation.
Certificate Of Analysis
|
Analysis Item |
Specification |
Test results |
|
Appearance |
White powder |
Conforms |
|
Solution clarity and color |
Clear and colorless |
Conforms |
|
Ammonium |
≤0.05% |
Conforms |
|
Phosphate |
≤0.1% |
Conforms |
|
Loss on drying |
≤6.0% |
Conforms |
|
Related impurity |
Single impurity≤0.3% |
0.01% |
|
|
Total impurity≤0.5% |
0.10% |
|
Heavy metals |
≤20ppm |
Conforms |
|
Assay |
98.0%-101.0% |
99.46% |
|
Conclusion |
Conforming to Enterprise Standard |
|
LL-37 Supplement
Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw materials. Besides, we handle every detail and reduce the cost to the maximum extent, then our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So you can look for Xi'an Sonwu Biotech Co. Ltd. when you need LL-37 Supplement.
Xi'an Sonwu completely makes sure of the product's quality, so samples can be supplied. Here is the quantity.
|
Form |
Sample Amount |
The Minimum of Quantity |
|
Powder |
1g |
5g |
Customers' Good Comment
What Is LL-37 Used For
It is a peptide that derived from human cathelicidin, a protein found in immune cells. It has antimicrobial properties, meaning it can help to kill or slow down the growth of different microorganisms, including bacteria, viruses, and fungi. It is a part of the innate immune system, which is the body's first line of defense against infections. The antimicrobial activity of LL-37 makes it potentially useful in various medical applications. Some of the potential uses include:
1. Antimicrobial Defense: It can kill a wide range of bacteria, viruses, fungi, and parasites by disrupting their cell membranes. It's effective against Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria. Besides, it can also neutralize bacterial endotoxins (LPS) to reduce inflammation. This product helps the body fight against a broad range of pathogens, making it a possible possibility for growing new antimicrobial specialists.
2. Wound Healing: It has been studied for its role in promoting wound healing. It may help tissue regeneration and speed up the overall healing process. It can enhance epithelial cell migration for faster wound closure and reduce chronic inflammation in wounds, helping in diabetic ulcers and skin injuries.
3. Anti-inflammatory Effects: It also possesses anti-inflammatory properties. It can modulate the immune response and may be involved in regulating inflammation. It can balance pro-inflammatory and anti-inflammatory effects to prevent excessive immune reactions.
4. Immunomodulation: It has been investigated for its immunomodulatory effects. It helps recruit immune cells to sites of infection, which means it can influence the activity of the immune system. This property could be beneficial in various immune-related conditions.
Research is progressing to investigate the remedial potential of LL-37 Powder in different medical contexts. It's important to note that while LL-37 shows promise in research, further studies and clinical trials are needed to establish its safety and efficacy for specific medical applications.
What Immune Responses Does LL-37 Modulate
LL-37, also known as cathelicidin, modulates several aspects of the immune response. Some of the immune responses that LL-37 can influence include:
1. Cytokine Production: It can adjust the development of cytokines, which are signaling molecules that play crucial roles in the immune system. It has been reported to both promote and inhibit the production of certain cytokines, depending on the specific context and the type of immune cells involved.
2. Chemotaxis: It has chemotactic properties, meaning it can attract and recruit immune cells to the site of infection or injury. This chemotactic activity helps to mobilize immune cells, such as neutrophils and monocytes, to areas where their presence is needed for defense and resolution of infection.
3. Wound Healing: It has been shown to promote wound healing through its immunomodulatory effects. It can influence the migration and activation of various cell types involved in wound repair, contributing to tissue regeneration and resolution of inflammation.
4. Regulation of Inflammatory Responses: It can modulate inflammatory responses by affecting the activation and function of immune cells, as well as by influencing the production of inflammatory mediators. Its immunomodulatory properties make it a significant figure controlling the harmony between supportive of incendiary and calming reactions.
5. Antigen Presentation: It may also influence antigen presentation, a key process in the adaptive immune response where immune cells display antigens to activate other immune cells, such as T cells. This can have implications for the regulation of adaptive immune responses.
These are some of the immune responses that LL-37 is known to modulate, highlighting its diverse roles in regulating the immune system's function. If you have further questions about specific aspects of LL-37's immunomodulatory effects, feel free to ask for more details.
What Is The Mechanism Of Action Of LL-37
It is a human antimicrobial peptide, which means it has the ability to kill or restrain the development of microorganisms, including bacteria, viruses, and fungi. The primary mechanism of action of LL-37 involves its interaction with microbial membranes. Here are the key steps in the mechanism:
1. Binding to Microbial Membranes: It is attracted to the negatively charged microbial membranes due to the presence of anionic components, such as lipopolysaccharides in bacterial membranes. The peptide binds to the surface of the microorganism, facilitating its interaction with the membrane.
2. Disruption of Membrane Integrity: It can disrupt the integrity of microbial membranes by forming pores or channels. The peptide has the ability to embed itself into the lipid bilayer of the microbial film.
3. Permeabilization of Membrane: Once inserted, it can increase the permeability of the microbial membrane. This permeabilization leads to leakage of essential intracellular components, such as ions and other molecules.
4. Disruption of Cellular Processes: The disruption of membrane integrity and permeabilization can interfere with vital cellular processes in microorganisms, leading to their death. It may also have additional immunomodulatory effects, influencing the host's immune response.
5. Anti-inflammatory Effects: It is not only involved in direct antimicrobial activity but also possesses anti-inflammatory properties. It can modulate the immune response by interacting with various host cells, including immune cells, and influencing cytokine production.
It is derived from the cleavage of cathelicidin, a precursor protein, and it is a key component of the innate immune system. Its broad-spectrum antimicrobial activity makes it an important part of the body's defense against infections. Additionally, research suggests that LL-37 may have therapeutic potential in conditions beyond infections, including wound healing and certain inflammatory disorders.
Factory
1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.
2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.
Certificate
Package
Logistics Update
In addition to guaranteeing product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
Company's Profile
Xi'an Sonwu Biotech Co., Ltd is a professional Chinese manufacturer and products supplier. It was founded in 2012 and is located in the Hi-Tech Industrial Zone, Xi'an City, Shannxi Province, China. It pays all attention to the development, research, and production of food additives, plants, extract, APl, and other ingredients of health care products. The company supplies five kinds of raw material products: Anti-hair loss Powders, Nootropic, API, Muscle Building products, and Plant Extract. Xi'an Sonwu sincerely believes that the premise of great cooperation is the best service and good quality. So, welcome your inquiry.
And if you want to know LL-37 Powder price or you need LL-37 Supplement, please contact XI'an Sonwu.
Email: sales@sonwu.com
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