Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of pregabalin powder in China. We warmly welcome yuo to wholesale bulk pregabalin powder for sale here from our factory. Quality products and reasonable price are available.
Is Pregabalin a Painkiller
Pregabalin powder is also called Lyrica powder, with the chemical name (S)-3-aminomethyl-5-methylhexanoic acid and the molecular formula C8H17NO2. It is a drug used to treat neuropathic pain, epilepsy and anxiety disorders. It is a γ-aminobutyric acid (GABA) analogue but does not directly act on GABA receptors. It reduces the release of neuronal excitatory transmitters (such as glutamate, norepinephrine and substance P) by binding to the α2δ subunit of voltage-dependent calcium channels, thereby exerting analgesic, anticonvulsant and anti-anxiety effects. It is mainly used for neuropathic pain (such as diabetic neuropathy postherpetic neuralgia), fibromyalgia syndrome, and as an adjunctive treatment for partial epileptic seizures and generalized anxiety disorder (GAD). If you need pregabalin, Xi'an Sonwu can supply it. Xi'an Sonwu is looking forward to hearing from you.
Certificate Of Analysis
|
ITEM |
STANDARD |
RESULT |
|
Appearance |
White or almost white crystalline powder |
White crystalline powder |
|
Specific rotation |
+9.0~ +11.5° |
+10.79° |
|
PH |
6.0~8.0 |
6.77 |
|
Loss on drying |
≤0.5% |
0.02% |
|
Residue on ignition |
≤0. 1% |
0.04% |
|
Heavy metals |
≤0.002% |
<0.002% |
|
Assay (on dried basis) |
≥98.5% |
100.8% |
|
R-pregabalin (HPLC) |
≤0.5% |
0.33% |
|
Related substances |
S-(+)-mandel ≤0. 1% |
0.3% |
|
Unspecific individual impurity≤0.4% |
0.08% |
|
|
Total impurities≤1.0% |
0. 10% |
|
|
Residual solvents |
Isopropylketone≤3000ppm Tetrahydrofuran≤720ppm |
585.0ppm ND |
|
Conclusion |
Comply with the enterprise standard |
|
Buy Pregabalin Online
Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and the health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw material. Besides, we handle every detail and reduce costs to the maximum so our customers can get cost-effective products. Based on these, customers have given a lot of good feedback about our products. So look for Xi'an Sonwu Biotech Co. Ltd. when buying pregabalin.
Xi'an Sonwu ensures product quality and can provide samples. Here is the quantity.
|
Pregabalin Form |
Sample Amount |
MOQ |
|
Powder |
100g |
100g |
|
Bulk Capsules |
1000 capsules |
1000 capsules |
|
Bottle Capsules |
10 bottles |
10 bottles |
Customers' Good Comment
OEM Service
Xi'an Sonwu can supply high-quality pregabalin capsules and powder.
So customers can customize the capsules they want. The items below can be supplied.
Customized capsule shells (size, colour, material)
Customized bottles(size, color, material, style)
Customized packaging(vacuum foil packaging, box, drum)
Customized label(paint film, matte film, optical mask)
Pregabalin Uses
Uses of Pregabalin
Pregabalin powder is a prescription medication widely used for its analgesic, anticonvulsant, and anxiolytic properties. Below are its primary uses:
1. Neuropathic Pain
Indications:
Diabetic peripheral neuropathy.
Postherpetic neuralgia (pain following shingles).
Pain associated with spinal cord injury.
Mechanism: Reduces abnormal nerve signalling by binding to the α2δ subunit of voltage-gated calcium channels, decreasing excitatory neurotransmitter release.
2. Fibromyalgia
Indication:
Alleviates widespread musculoskeletal pain and associated fatigue.
Mechanism: Modulates pain perception by altering nerve transmission in overactive pain pathways.
3. Epilepsy
Indication:
Used as an adjunctive therapy for partial-onset seizures in adults.
Mechanism: Stabilizes overactive neurons, reducing seizure frequency.
4. Generalized Anxiety Disorder (GAD) (Approved in some countries)
Indication:
Relieves excessive anxiety and tension.
Mechanism: Modifies the release of neurotransmitters, providing a calming effect.
5. Off-Label Uses
Chronic pain syndromes:
Central neuropathic pain.
Chemotherapy-induced neuropathy.
Restless legs syndrome (RLS):
It helps reduce discomfort and improve sleep.
Migraine prophylaxis:
It may be considered in refractory cases.
Lyrica Benefits
Provides rapid relief for neuropathic pain.
Reduces seizure burden when combined with other anticonvulsants.
Improves sleep and overall quality of life in fibromyalgia and anxiety patients.
While it is highly effective for these conditions, its use must be guided by a healthcare professional to mitigate risks like side effects or dependency. Always follow prescribed dosages and treatment plans.
Does Pregabalin Affect The Kidneys
It is primarily eliminated through the kidneys, so its use requires careful consideration in individuals with kidney (renal) impairment. Here's how it may affect the kidneys and considerations for its use:
A. Effects of Lyrica on the Kidneys
1. No direct nephrotoxicity:
It is not inherently harmful to kidney function. It does not damage the kidneys directly in people with normal renal function.
2. Renal clearance:
It is excreted unchanged in the urine, meaning the kidneys are responsible for eliminating the drug from the body.
In patients with impaired kidney function, drug accumulation can occur, leading to an increased risk of side effects.
3. Rare adverse effects:
Cases of acute kidney injury have been reported but are rare and often occur in patients with predisposing factors (e.g., dehydration and other nephrotoxic medications).
If kidney function worsens during treatment, other underlying causes are usually investigated.
B. Lyrica Use in Kidney Disease
1. Dose adjustment:
It doses must be reduced in patients with renal impairment based on their creatinine clearance (CrCl) levels.
Severe kidney disease (e.g., end-stage renal disease) often requires adjusting both the dose and the dosing frequency.
2. Dialysis considerations:
It is removed during dialysis, so an additional dose may be needed post-dialysis to maintain therapeutic levels.
C. Monitoring Kidney Function
Before starting therapy, Baseline kidney function tests (e.g., serum creatinine, eGFR) are often recommended.
During treatment: Patients with pre-existing renal impairment may require periodic kidney function monitoring.
D. When to Avoid or Use Caution
Patients with severe renal impairment should use it under strict medical supervision.
Those with conditions like diabetes or hypertension (common causes of kidney damage) may need extra monitoring while on it.
While Lyrica itself does not harm the kidneys, its use in people with existing kidney problems requires careful dose adjustments and monitoring. If you are concerned about kidney health while using it, discuss it with your healthcare provider.
What Not To Take With Pregabalin
When taking it, certain medications and substances should be avoided or used cautiously due to potential interactions or enhanced side effects. Below are key considerations:
A. Medications/Substances to Avoid or Use with Caution
1. CNS Depressants
Examples: Alcohol, benzodiazepines (e.g., diazepam, lorazepam), opioids (e.g., morphine, oxycodone), sleep aids (e.g., zolpidem).
Risk: Enhanced sedative effects, leading to excessive drowsiness, dizziness, impaired coordination, and respiratory depression.
2. Other Anticonvulsants
Examples: Gabapentin, carbamazepine, phenytoin.
Risk: It may increase the risk of additive side effects like sedation and dizziness; dose adjustments may be necessary.
3. Antihistamines (sedating types)
Examples: Diphenhydramine chlorpheniramine.
Risk: Increased drowsiness and cognitive impairment.
4. Muscle Relaxants
Examples: Baclofen tizanidine.
Risk: Enhanced sedation and risk of falls or accidents.
5. Tricyclic Antidepressants (TCAs) and MAO Inhibitors
Examples: Amitriptyline, nortriptyline.
Risk: Increased risk of central nervous system side effects like dizziness and confusion.
6. Diabetes Medications
Examples: Thiazolidinediones (e.g., pioglitazone, rosiglitazone).
Risk: It may increase the risk of peripheral oedema (swelling), which these drugs can also cause.
7. NSAIDs or Other Medications with Renal Impact
Examples: Ibuprofen, naproxen, certain antibiotics.
Risk: Patients with kidney impairment should avoid combining drugs that may further stress renal function.
B. Substances to Avoid
1. Alcohol:
Amplifies sedative effects and can impair coordination and cognitive function.
2. Illicit Drugs:
It has abuse potential; combining it with other substances increases the risk of dependency or overdose.
C. Other Considerations
1. Driving or Operating Machinery:
It may cause drowsiness and dizziness. Combining it with other sedatives increases the risk of accidents.
2. Dietary Supplements and Herbal Products:
Some supplements (e.g., St. John's Wort) may interact unpredictably; always inform your doctor about any supplements you are taking.
D. Key Advice
Always inform your healthcare provider about all medications, supplements, and substances you are using before starting it.
Make sure to consult your doctor before making changes to your medication regimen.
Proper management and awareness of these interactions can reduce risks and improve the effectiveness of pregabalin therapy.
Factory
1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.
2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.
Certificate
Packing
Logistics Update
In addition to guaranteeing product quality, the other most vital thing is that clients receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
FAQ
1. How to inquire?
We can be reached by phone, email, or social media.
2. How do you guarantee the quality of products?
Each batch must be tested, and COA can be supplied to customers. Additionally, all the products pass the test: HPLC, UV, GC, TLC, etc. We cooperate with third parties as well, like SGS.
3. How do you pack and store?
Pack: Use sealed export-grade drums and vacuum-sealed foil packaging, or pack the goods according to customers' needs.
Storage: You can keep it in a dry and cool place and make it avoid sunlight.
If you want to know about the pregabalin powder, you can contact Xi'an Sonwu. Click the email, and then you get high-quality lyrica powder.
Email: sales@sonwu.com
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