Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of nad powder in China. We warmly welcome yuo to wholesale bulk nad powder for sale here from our factory. Quality products and reasonable price are available.
NAD+ Supplement
NAD powder is short for nicotinamide adenine dinucleotide, referred to as coenzyme I. It is a kind of molecule that exists in all of the live cells, which is crucial to metabolism and other main molecules' function. NAD exists in two forms: NADH and NAD+. The ability to switch between these two forms makes NAD realize its core function which is bringing electrons from one reaction to another during metabolism and the production of energy.
Coenzyme I is present in all biological cells, and it can be said that nothing can survive without coenzyme I. It connects the tricarboxylic acid cycle and the respiratory chain and can play the role of transferring hydrogen removed during metabolism to flavoproteins. In addition, it also plays a vital role in metabolism and DNA repair.
NAD+ is an indispensable substance for activating acetylase, which decreases with age. As an essential substance for life, its market demand is also growing. If you want to find a pure NAD supplier, you can contact Xi'an Sonwu.
Certificate of Analysis
Testing Items | Specifications | Results |
Appearance | White to yellowish powder or crystalline powder | Conforms |
Identification | Conform with NMR | Conforms |
Na Content (ICP-OES) | ≤0.5% | 0.003% |
Water | ≤10.0% | 8.4% |
PH | 2.0-4.0 | 2.9 |
Purity (HPLC) | ≥98.5% | 99.60% |
Assay | ≥97.0% | 99.52% |
Heavy metal | ||
Lead(Pb) | ≤0.5ppm | 0.314ppm |
Arsenic(As) | ≤0.5ppm | N.D |
Cadmium(Cd) | ≤0.5ppm | 0.001ppm |
Mercury(Hg) | ≤0.5ppm | 0.006ppm |
Spectroscopy Detection | ||
A340/A260 | 0.39-0.47 (0.43±0.04) | 0.43 |
A250/A260 | 0.75-0.91 (0.83±0.08) | 0.83 |
A280/A260 | 0.19-0.23 (0.21±0.02) | 0.21 |
ε260 (pH=7.5) | 16.2-19.8(103L·mol-1·cm-1) (18.0±1.8)×103 | 18.2×103 |
Residual Solvent | ||
Methanol | ≤1.0% | 0.08% |
Ethanol | ≤2.0% | N.D |
Microbial | ||
Colonies Number | ≤750CFU/g | 9CFU/g |
Escherichia Coli | <3MPN/g | N.D |
What is NAD+ Main Function?
NAD powder could supply energy to our bodies. It has many benefits:
1. Anti-aging
NAD can activate human longevity factors, maintain telomere length, and prolong life. It is a nutrient necessary for the function of deacetylase histones, dubbed "longevity factors" by scientists, and in particular, maintains key telomere length, slows the aging process and prolongs lifespan. A total of 7 isoforms from SIRT1 to SIRT7 make up the Sirtuins protein family, which also constitutes a "longevity factor". It also improves DNA's ability to repair itself and prolongs lifespan by reversing the mitochondrial decline. This includes reducing stress, neutralizing inflammatory responses, protecting against DNA and mitochondrial damage, and slowing the rate of cellular aging.
NAD is also a coenzyme that promotes cells to generate energy from nutrients. Adequate NAD levels can ensure cell energy supply and promote cell regeneration. This is a vital factor in slowing the aging of the immune system, defending against infection, and developing autoimmune diseases. Among other things, it can improve chromosomal stability, which can slow cellular aging and reduce the risk of many diseases.
2.Improve Immunity.
NAD gradually decreases with age. After the age of 30, there will be a situation of "making ends meet"; when we reach the age of 40 to 60, the loss of NAD+ is nearly 50%; at the age of 60, the NAD content in the human body is only about 12.5% of the initial level. At the same time, in addition to spontaneous damage, external factors such as physical factors (ultraviolet rays, ionizing radiation) and chemical factors (environmental pollution, drugs) will further accelerate genetic damage and accelerate the aging process.
During DNA repair, the demand for PARP1 (DNA repair enzyme) increases; the activity of SIRT is limited; NAD+ consumption increases; and the amount of NAD+ naturally decreases. NAD+ supplementation modulates the activity of proteases such as CD38, which directs a range of physiological activities. Besides, it can also regulate PARPs that can repair DNA, resulting in a reduction in pro-inflammatory cytokines and restoration of immune function.
3. Prevention and treatment of vascular disease
The pathophysiology of vascular diseases is complex, mainly involving metabolic disorders, oxidative stress, and inflammation. As a common substrate of a variety of key enzymes, NAD generally participates in important biological processes in the body. It is involved in the signaling pathways of cardiovascular disease and can have a repairing effect on cardiovascular disease by regulating metabolism, maintaining redox homeostasis, and modulating immune responses. At the same time, the intake of NAD supplements can also delay aging through various molecular pathways, thereby intervening in the occurrence and deterioration of the cardiovascular disease, a typical aging-related disease.
Heart failure is one of the common cardiovascular diseases, and mitochondrial dysfunction is one of the main causes of heart failure. So restoring or improving mitochondrial health has important therapeutic implications. Fortunately, NAD has beneficial effects on the regulation of metabolism, redox homeostasis, anti-inflammatory, and maintenance of mitochondrial homeostasis. In the future, NAD may be applied to the primary prevention of cardiovascular disease, and even become an effective target for the treatment of common cardiovascular diseases such as coronary heart disease and arrhythmia.
Nicotinamide Adenine Dinucleotide Side Effects
NAD is a very important substance for the human body to maintain life, and it is generally well tolerated. But still, need to pay attention to the side effects. Its usual side effects are fatigue, irritability, insomnia, and indigestion.
Role of NAD in Metabolism
NAD is highly compartmentalized in the cytoplasm, mitochondria, and nucleus, which represents its main subcellular pools. It is a critical metabolite and coenzyme for multiple metabolic pathways and cellular processes.
First, NAD reduction is required to maintain energy balance and the redox state of a cell. In human cells, NAD is consumed and metabolized mainly in three ways:
1. PARPs pathway for DNA repair;
2. The sirtuins pathway, which is depleted to turn on longevity genes;
3. CD38 pathway for calcium signaling.
PARPs are key enzymes that prompt cells to respond to abnormal stimuli. Severe external invasions will trigger persistent activation of PARPs, resulting in NAD depletion and cell death; the sirtuins protein family is a class of highly evolutionarily conserved deacetylases. They can bind and consume NAD, and adjust cellular oxidative metabolism. CD38 is required to produce secondary messengers such as ADPR, 2dADPR, NAADP, and cADPR by consuming NAD to guide a series of physiological activities.
Therefore, NAD mediates multiple major biological processes and is always in high demand. It is constantly synthesized, catabolized, and recycled in the cell to maintain stable intracellular NAD levels. However, during aging, this balance between catabolic and anabolic processes sometimes changes. To maintain this balance, timely NAD supplements are essential.
NAD Powder Reddit
FAQ
What is the recommended dosage?
For average adults, NAD powder take in 250-300 mg per day is good. But the accurate data varies from different persons. You can consult doctors.
2. When should i take this supplement?
30 minutes before a meal on an empty stomach ia advised.
There are more and more platforms selling NAD in the market. If you are interested in this products, you can contact Xi'an Sonwu directly.
Email:sales@sonwu.com
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