Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of lyrica powder in China. We warmly welcome yuo to wholesale bulk lyrica powder for sale here from our factory. Quality products and reasonable price are available.
Lyrica (Pregabalin)
Lyrica powder, another name for pregabalin, is a member of the gabapentin medication class that binds to calcium channels in the central nervous system to lessen the release of specific molecules involved in sending pain signals. It is mainly employed to treat neuropathic pain, a type of discomfort brought on by nerve injury. This medication treats fibromyalgia, a condition characterized by widespread musculoskeletal discomfort, and manages seizures. Neuropathic pain can be caused by various shapes, including diabetic neuropathy, postherpetic neuralgia (a complication of shingles), and spinal cord injury. It is characterized by a stinging or burning pain, often accompanied by tingling or numbness in the affected area. It has been shown to help reduce these symptoms and improve patient's quality of life. In addition to treating neuropathic pain, it is also approved for fibromyalgia. The muscles, tendons, and joints of those with fibromyalgia experience extensive pain, tiredness, and discomfort. It is believed to be caused by abnormalities in how the central nervous system processes pain signals. Lyrica can help fibromyalgia patients reduce pain and improve sleep. If you have this type of nerve pain or fibromyalgia problem and are considering pregabalin, you can contact Xi'an Sonwu; Xi'an Sonwu can provide you with the wholesale pregabalin.
Certificate Of Analysis
|
Item |
Standard |
Result |
|
Appearance |
White or almost white crystalline powder |
White crystalline powder |
|
Specific rotation |
+9.0~ +11.5° |
+10.79° |
|
PH |
6.0~8.0 |
6.77 |
|
Loss on drying |
≤0.5% |
0.02% |
|
Residue on ignition |
≤0. 1% |
0.04% |
|
Heavy metals |
≤0.002% |
<0.002% |
|
Assay (on dried basis) |
≥98.5% |
100.8% |
|
R-pregabalin(HPLC) |
≤0.5% |
0.33% |
|
Related substances |
S-(+)-mandel ≤0. 1% |
0.3% |
|
Unspecific individual impurity≤0.4% |
0.08% |
|
|
Total impurities≤1.0% |
0. 10% |
|
|
Residual solvents |
Isopropylketone≤3000ppm Tetrahydrofuran≤720ppm |
585.0ppm ND |
|
Conclusion |
Comply with the enterprise standard |
|
Where To Buy Pregabalin
Xi'an Sonwu Biotech Co. Ltd. has over ten years of industry experience producing and selling raw materials. Xi'an Sonwu has established solid and reliable partnerships with countries in America, Asia, Europe, and Oceania. Xi'an Sonwu puts product quality first and strives to provide every customer with high-quality services to meet their needs fully.
Xi'an Sonwu prioritizes high-quality products, and its commitment to excellence is evident in every aspect, including material selection, manufacturing techniques, sample testing, and the professionalism of its personnel. By meticulously managing every detail, Xi'an Sonwu can minimize costs without compromising quality, ensuring customers receive products of exceptional value.
Xi'an Sonwu is proud of the positive feedback it has received from customers, who have consistently recognized the quality of the products. To further prove product confidence, Xi'an Sonwu will provide samples for you to test.
|
Pregabalin Form |
Sample Amount |
The Minimum Of Quantity |
|
Powder |
50g |
100g |
Customers' Good Comment
How Does Pregabalin Work
Lyrica powder is an analog of the neurotransmitter GABA and a follow-up product to gabapentin. Although it shares a structural resemblance with the neurotransmitter GABA, it does not function similarly. Different from traditional anti-epileptic drugs, within the effective concentration range, it does not interact with GABAA or GABAB receptors, does not metabolize into GABA or GABA agonists, does not inhibit the uptake and degradation of GABA, and does not act on sodium and calcium channels. And the release and uptake of glutamate. At the same time, it does not show affinity with active amino acid receptors such as glutamate and GABA. It can still prevent tagged GABA from binding to calcium ion channel subunits 2 and 3, which inhibits the central nervous system. A subunit of voltage-dependent calcium channels called 2-protein decreases calcium ion inflow, affecting GABAergic neurotransmission and releasing excitatory neurotransmitters like glutamate, norepinephrine, and substance P. These channels are present in nerve cells and transmit pain signals. When calcium channels are activated, they allow calcium ions to enter nerve cells, triggering the release of certain neurotransmitters.
Gamma-aminobutyric acid, a neurotransmitter, is increased in the brain by it. An inhibitory neurotransmitter called GABA aids in controlling the excitability of nerve cells. By increasing GABA levels, it may help further suppress abnormal transmission of pain signals in the central nervous system. Pregabalin is particularly effective in treating neuropathic pain because it controls neurotransmitter release and stops excessive neuronal activity. It aids in the restoration of the aberrant pain signals linked to the condition. Neuropathic pain is brought on by nerve injury or dysfunction.
What Is Pregabalin Used To Treat
1. Neuropathic pain
Pregabalin is approved to treat neuropathic pain caused by nerve damage that may result from diabetic neuropathy, postherpetic neuralgia (a complication of shingles), and spinal cord injury.
2. Fibromyalgia
The chronic disorder fibromyalgia, characterized by widespread musculoskeletal pain, exhaustion, and discomfort in muscles, tendons, and joints, is also treated with it.
3. Partial epileptic seizures
Pregabalin is approved as adjunctive therapy for treating partial-onset seizures in adults with epilepsy. Combined with other anti-epileptic drugs, it can help reduce the frequency of seizures and improve seizure control.
4. Generalized Anxiety Disorder (GAD)
A prevalent psychological condition called generalized anxiety disorder is characterized by excessive and ongoing worry and physical symptoms such as muscle tension, exhaustion, trouble concentrating, and sleep difficulties. Research shows that it has specific efficacy in treating generalized anxiety disorder.
5. Restless legs syndrome (RLS)
Patients experience discomfort, tingling, or throbbing in their legs while resting or sleeping, forcing them to move their legs to relieve symptoms. Symptoms are usually most severe at night and while sleeping and can interfere with sleep and lead to poor sleep quality. It is sometimes used off-label to treat restless legs syndrome.
Pregabalin VS Gabapentin
Pregabalin and gabapentin are both drugs that belong to the gabapentin class. They have similar structures and mechanisms of action, but some differences exist.
Approved Uses: Pregabalin has been given the go-ahead to treat partial-onset seizures and the neuropathic pain brought on by postherpetic neuralgia, fibromyalgia, and diabetic neuropathy. Gabapentin is approved to treat postherpetic neuralgia, partial seizures, and restless legs syndrome.
Pharmacokinetics: Pregabalin has higher oral bioavailability and a more predictable absorption profile than gabapentin. Pregabalin is absorbed more rapidly and exhibits linear pharmacokinetics. It is also primarily excreted unchanged via the kidneys and has a shorter elimination half-life than gabapentin.
Dosage and Administration:
Pregabalin and gabapentin have different dosing regimens. Pregabalin is usually given in two or three doses daily, while gabapentin may require more frequent dosing due to its shorter half-life. Specific dosage and titration regimens will depend on the patient's condition and individual response.
Potency: Pregabalin is considered more potent than gabapentin, which means that lower doses of it may be required to achieve the desired therapeutic effect compared to gabapentin. It has been shown in laboratory experiments to have anticonvulsant effectiveness against a variety of animal models of epilepsy; however, the action of it is 3 to 10 times greater than that of gabapentin.
Side effect:
Dizziness, drowsiness (extreme sleepiness), peripheral edema (swelling of the extremities), and weight gain are adverse effects that both medications can potentially produce. Pregabalin, on the other hand, may be linked to a lower rate of adverse effects than gabapentin, according to specific research.
Factory
1. Xi'an Sonwu Biotech Co., Ltd has a factory to produce, manufacture, and store the products, so it has adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.
Certificate
Package
Logistics
Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
FAQ
Dosage
1. Adjuvant treatment of partial seizures of epilepsy:
(1) 50 mg three times a day, or 75 mg once, twice. Depending on the patient's response and tolerance, the dosage can be 600 mg daily in two to three divided doses.
(2) Add pregabalin at 150 to 600 mg per day, divided into 2 to 3 times, for individuals with uncontrollable epilepsy who are not responding to other anti-epileptic medications.
2. Neuralgia due to diabetic peripheral neuropathy: The initial dose is 50 mg once, three times a day; depending on efficacy and tolerance, it can be increased to 100 mg once, three times a day, within one week.
3. Postherpetic neuralgia: 75 mg twice or 50 mg three times daily is the recommended starting dose; it can be increased to 300 mg daily within a week, depending on the treatment effect and tolerance. The maintenance dose is 75 to 150 mg twice daily or 50 to 100 thrice daily.
4. Generalized anxiety disorder: 300 to 600 mg a day.
5. Social phobia: 200mg once, three times a day.
If you want to know the pregabalin API powder manufacturer, you can contact Xi'an Sonwu. Click the email, and then you get high-quality lyrica powder.
Email: sales@sonwu.com
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