Irinotecan HCL Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of irinotecan hcl powder in China. We warmly welcome yuo to wholesale bulk irinotecan hcl powder for sale here from our factory. Quality products and reasonable price are available.

Irinotecan Hydrochloride
Irinotecan HCL powder (CPT-11) is a semisynthetic soluble camptothecin derivative that belongs to a class of topoisomerase inhibitors and is primarily used to treat advanced colorectal disease and gastric disease. Topoisomerase I is an enzyme involved in the DNA replication process, helping to unwind the supercoiled structure of DNA for replication. Irinotecan binds to topoisomerase I, preventing its normal DNA unwinding function and leading to instability and breakage of the DNA chain. This effect can trigger DNA synthesis errors and cell apoptosis, which is particularly significant in diseased cells, thereby inhibiting the proliferation and spread of diseased cells. This mechanism makes irinotecan hydrochloride a powerful tool in treating severe and malignant diseases. It mainly acts in the S phase of the cell cycle. It is metabolized into an active product in the body and is catalyzed by carboxylesterase to generate 7-ethyl-10-hydroxycamptothecin (SN-38). Its anti-lesion activity is 100~ 1000 times. Irinotecan hydrochloride is often used as part of a chemotherapy regimen, usually in combination with other chemotherapy drugs, and can be combined with fluorouracil and leucovorin. It can also be used as a stand-alone treatment for individuals who have failed fluorouracil chemotherapy or who have advanced colorectal disease but have never had chemotherapy. If you are also interested in chemotherapy drugs, please get in touch with Xi'an Sonwu. Xi'an Sonwu can provide you with pure irinotecan hydrochloride powder.

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Xi'an Sonwu Biotech Co. Ltd. has more than ten years of industry experience, specializing in producing and selling raw materials. Xi'an Sonwu has established solid and reliable partnerships with countries in America, Asia, Europe, and Oceania. Xi'an Sonwu puts product quality first and strives to provide every customer with high-quality services to meet their needs fully.
Xi'an Sonwu prioritizes high-quality products, and its commitment to excellence is evident in every aspect, including material selection, manufacturing techniques, sample testing, and the professionalism of its personnel. By meticulously managing every detail, Xi'an Sonwu can minimize costs without compromising quality, ensuring customers receive products of exceptional value.
Xi'an Sonwu is proud of the positive feedback it has received from customers, who have consistently recognized the quality of the products. To further prove product confidence, Xi'an Sonwu will provide samples for you to test.

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What Is The Mechanism Of Action Of Irinotecan Hydrochloride
Irinotecan HCL powder is a topoisomerase I inhibitor (L-antipathogenic and immunosuppressant) that inhibits cell growth. Metabolized to SN-38 by carboxylesterases in most tissues, SN-38 or irinotecan can induce single-stranded DNA damage, thereby blocking DNA replication forks, resulting in cytotoxicity. This cytotoxicity is time-dependent and specific to the S phase. In in vitro experiments, irinotecan and SN-38 were not found to be effectively recognized by P-glycoprotein MDR and showed cytotoxic effects on cell lines resistant to doxorubicin and vinblastine. In addition, in in vivo experiments, irinotecan showed broad-spectrum anti-disease activity in murine lesion models (PO3 pancreatic duct adenocarcinoma, MA-16/C breast disease, C38, and C51 colon adenocarcinoma), and has anti-human xenogeneic Viability of transplanted cells (Co-4 colon adenocarcinoma, MX-1 breast disease, St-5, and SC-6 gastric adenocarcinoma). Irinotecan also has anti-disease activity against cells expressing P-glycoprotein MDR (vincristine- and doxorubicin-resistant P388 leukemias). In addition to its anti-disease training, this product's most relevant pharmacological effect is the inhibition of acetylcholinesterase.

What Is Irinotecan Hydrochloride Used For
1. Colorectal diseases
Colorectal disease is a malignant group of cells originating in the colon or rectum. It usually develops in the mucosal cells within the colon or rectum and may gradually spread to surrounding tissues and organs. It is a common type of lesion that generally occurs more frequently in older people. Colorectal disease may cause symptoms such as changes in bowel habits, constipation, diarrhea, bloody stools, anemia, abdominal pain, etc., but may be asymptomatic in the early stages. Through its mechanism of action, irinotecan can help control and slow the progression of advanced colorectal disease.

2. Lung disease
A malignant disease that typically develops in lung tissue is called lung disease. There are two forms of lung disease: non-small-cell lung disease and small-cell lung disease. Long-term exposure to smoking, pollution from the environment, or other carcinogens is typically the cause. Early lung disease may not cause noticeable symptoms, but as the cell grows, patients may develop symptoms such as cough, bloody sputum, difficulty breathing, chest pain, and weight loss. Irinotecan hydrochloride is a targeted drug that inhibits cell growth and spread by inhibiting specific signaling pathways in bad cells. Patients with certain epidermal growth factor receptor kinase mutations with non-small lung disease are frequently treated with it. In clinical practice, irinotecan hydrochloride has been widely used in treating advanced non-small cell lung disease patients and has shown significant efficacy in some cases.

3. Leukemia
The unchecked growth of aberrant white blood cells in the bone marrow is the cause of leukemia. The kind and rate of white blood cell growth distinguishes acute and chronic leukemia. Leukemia can cause abnormal white blood cells to be produced by the bone marrow while preventing the production of regular blood cells such as red blood cells, platelets, and other white blood cells. That can result in symptoms such as anemia, infection, and bleeding.

4. Hydatidiform mole
A molar pregnancy is a rare pregnancy-related condition that usually occurs in the uterus and is an abnormal placental tissue produced by an ectopic pregnancy. This condition can cause tissue in the uterus to increase abnormally, and the fetus does not develop properly. A molar pregnancy usually presents with abnormal pregnancy symptoms, such as vaginal bleeding, uterine cavity enlargement, and increased intrauterine pressure. Adjuvant chemotherapy may be required in certain situations, and the standard course of treatment entails surgical dilatation and curettage to remove aberrant tissue. Systemic chemotherapy might be necessary in extreme cases to stop the disease's progression.

5. Chorionic epithelial diseases
Chorioepithelial carcinoma is a rare but severe malignancy usually occurring in placental tissue. This type of disease usually appears during pregnancy, but it can also happen later in pregnancy or after childbirth. Chorioepithelial carcinoma typically presents with vaginal bleeding, enlargement of the uterine cavity, and pregnancy-related symptoms.

What Is The Main Side Effect Of Irinotecan
(1) Digestive system
① diarrhea occurring 24 hours after taking this product is the drug-limiting toxicity of this product. About 20% of patients will develop severe diarrhea that requires treatment when taking the drug alone. Delayed diarrhea usually occurs five days after taking the medicine. Combination medication: The incidence of delayed diarrhea is 13.1%, and bacterial infectious diarrhea is sporadic.
②Nausea and vomiting: Single medication: about 10% of patients experience severe nausea and vomiting; combined pill: about 2.1% to 2.8% of patients experience severe nausea and vomiting.
(2) Hematological toxicity
Granulocytopenia is reversible and non-cumulative. The median time to go through neutropenia was eight days with either monotherapy or combination therapy. Approximately 78.7% of patients experienced granulocytopenia, 58.7% experienced anemia, and 7.4% experienced thrombocytopenia when used alone. When combined, 82.5% of patients experienced granulocytopenia and 97.2% experienced neutropenia. Anemia: 32.6% of patients had thrombocytopenia (platelets <101000/mm3).
(3) Acute cholinergic syndrome: the incidence rate of single medication is 9%, and the incidence rate of combined drugs is 1.4%. Symptoms such as acute diarrhea, abdominal pain, conjunctivitis, rhinitis, hypotension, vasodilation, hyperhidrosis, syncope, dizziness, blurred vision, myositis, and tearing appear within 24 hours after taking the drug.
(4) Other adverse reactions
Other adverse reactions will be breathing difficulties, muscle spasms, and paresthesia.

Factory
1. Xi'an Sonwu Biotech Co., Ltd has a factory to produce, manufacture, and store the products, so it has adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.

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Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ
Contraindications
(1) Patients with chronic enteritis and intestinal obstruction.
(2) Those with a history of severe allergy to irinotecan hydrochloride trihydrate or the excipients in this product.
(3) Bilirubin exceeds three times the upper limit of the average value.
(4) Severe bone marrow insufficiency; pregnancy or lactation.
Furthermore, it is necessary to notice how irinotecan and neuromuscular blockers interact. It has anticholinesterase activity. Drugs with anticholinesterase activity can prolong the neuromuscular blocking effect of succinylcholine. Non-depolarizing neuromuscular blockers may be antagonized.

If you want to know the irinotecan hydrochloride powder manufacturer, you can contact Xi'an Sonwu. Click the email, and then you get high-quality irinotecan HCL powder.
Email: sales@sonwu.com

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