Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of darunavir ethanolate api in China. We warmly welcome yuo to wholesale bulk darunavir ethanolate api for sale here from our factory. Quality products and reasonable price are available.
What Is Darunavir Ethanolate
Darunavir Ethanolate API is an antiretroviral medication primarily used in the treatment of HIV-1 infection. It is a protease inhibitor (PI), a class of drugs that works by inhibiting HIV protease, an enzyme necessary for the virus's reproduction. In highly active antiretroviral therapy or combination antiretroviral therapy, darunavir is typically used in conjunction with other antiretroviral medications. This combination therapy is designed to reduce viral load, increase CD4+ T-cell counts, and improve overall quality of life for people living with HIV. Darunavir ethanolate is a prodrug, which means that it is metabolized into its active form in the body. The ethanolate form improves the solubility and absorption of the drug, which is crucial for its efficacy.
Certificate Of Analysis
|
Item |
Specification |
Result |
|
Appearance |
White powder |
Conforms |
|
Identification |
(1)304nm,260nm. |
Conforms |
|
Specific rotation |
+124°~ +129° |
+127.1° |
|
Related substances |
(1)Single: ≤0.5% |
0.31% |
|
|
(2)Total: ≤1.0% |
0.59% |
|
Loss on drying |
≤0.5% |
0.1% |
|
Assay |
≥98.0% |
99.5% |
|
Conclusion |
Conforming to Enterprise Standard |
|
Where To Buy Darunavir Ethanolate
Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw materials. Besides, we handle every detail and reduce the cost to the maximum extent, then our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So you can look for Xi'an Sonwu Biotech Co. Ltd. when you want to buy Darunavir Ethanolate Powder.
Xi'an Sonwu completely makes sure of the product's quality, so samples can be supplied. Here is the quantity.
|
Form |
Sample Amount |
The Minimum of Quantity |
|
Powder |
50g |
100g |
Customers' Good Comment
What Is Darunavir Ethanolate Used For
Darunavir ethanolate is primarily used for the treatment of HIV-1 infection, the virus responsible for human immunodeficiency virus (HIV). Specifically, it is utilized as part of cART or HAART to suppress HIV replication, improve immune function, and reduce the risk of developing AIDS. Here are the main indications for darunavir ethanolate:
1. Treatment of HIV-1 Infection (Adult and Pediatric):
Darunavir ethanolate is used to treat HIV-1 infection in both treatment-naive and treatment-experienced patients:
Treatment-Naive Patients: Darunavir is part of initial treatment regimens for patients who have never been treated for HIV.
Treatment-Experienced Patients: It is particularly important in patients who have developed resistance to other antiretroviral medications, including other protease inhibitors. Darunavir is a viable treatment option for individuals with multidrug-resistant HIV because of its high genetic barrier to resistance, which requires the virus to mutate several times before it becomes resistant to the medication.
2. HIV-1 Resistance:
Darunavir is especially beneficial for patients who have strains of HIV resistant to other PIs or other classes of antiretroviral drugs. Due to its high resistance barrier, it is often prescribed when other treatment options are no longer effective, particularly in treatment-experienced individuals.
3. Pregnancy (With Caution):
Darunavir is used during pregnancy in women living with HIV to prevent vertical transmission (mother-to-child transmission) of the virus. However, it is classified as Category C (risk cannot be ruled out), so its use should be closely monitored, and the potential benefits must outweigh any possible risks to the fetus.
4. Combination Therapy:
Darunavir is typically used in combination with other antiretroviral drugs. It is almost never used as a monotherapy for HIV treatment due to the risk of developing drug resistance. In combination therapy, darunavir works alongside other classes of drugs such as NRTIs or NNRTIs to provide a more effective and comprehensive treatment regimen.
In summary, Darunavir Ethanolate API is mainly used for managing HIV-1 infection in both new and experienced patients, including those with drug-resistant strains of the virus. It is a key component in combination therapy regimens designed to control HIV, improve immune function, and reduce the risk of AIDS.
How Does Darunavir Work
Darunavir is an HIV protease inhibitor that works by targeting and inhibiting the HIV-1 protease enzyme, a crucial enzyme in the HIV life cycle. By blocking this enzyme, darunavir prevents the virus from replicating, thereby controlling the infection. Let's break down how darunavir works in detail:
1. Targeting HIV Protease
HIV, like all viruses, requires a series of steps to reproduce within human cells. One of these steps involves the HIV-1 protease, an enzyme that plays a very important role in the maturation of new viral particles. The HIV protease is responsible for cleaving polyproteins (long precursor proteins) into smaller, functional proteins that are necessary for the assembly of new, infectious viral particles.
HIV Protease Function: During the virus's replication cycle, the HIV protease enzyme cleaves large polyproteins into smaller components, which then form the structural proteins and enzymes required to assemble a new virus. Without proper cleavage, the virus cannot produce mature, infectious virions.
2. Mechanism of Action of Darunavir
Darunavir works by inhibiting the action of the HIV-1 protease enzyme. It binds tightly to the protease enzyme and prevents it from cleaving the polyproteins. As a result, the virus is unable to mature properly, and the newly formed virions remain immature and non-infectious.
Inhibition of Protease Activity: By blocking the protease, darunavir effectively prevents the production of mature, infectious HIV particles. This inhibition prevents the virus from replicating and spreading to other cells.
Viral Maturation Block: The inability to cleave polyproteins into functional units results in immature viral particles that are biologically inactive and cannot infect new cells. The process of virion maturation is arrested.
3. High Barrier to Resistance
One of the key advantages of darunavir is its high genetic barrier to resistance. HIV can mutate rapidly, and resistance to antiretroviral drugs can emerge through mutations in the viral genome. However, darunavir is designed with structural modifications that allow it to remain effective even in the presence of certain mutations in the HIV-1 protease enzyme.
Resistance Mutations: HIV strains resistant to other protease inhibitors may still be susceptible to darunavir because the drug binds very tightly to the protease enzyme. Even if the virus mutates, it often requires multiple mutations to escape darunavir's effects.
Higher Potency: Darunavir's potency means that it can effectively suppress the virus even in individuals with drug-resistant strains of HIV, making it an important option for treatment-experienced patients.
4. Pharmacokinetics and Bioavailability
Darunavir is often administered with ritonavir, a drug that boosts the bioavailability of darunavir by inhibiting its metabolism (through CYP3A4, a liver enzyme). This combination allows for higher and more consistent drug levels in the bloodstream, making the therapy more effective.
Prodrug Form: Darunavir ethanolate Powder is a prodrug, which means it is metabolized in the body to its active form. The ethanolate salt improves the solubility and absorption of the drug, ensuring more consistent plasma concentrations when taken orally.
Long Half-Life: Darunavir has a relatively long half-life, allowing for once-daily dosing in many cases, which helps improve patient adherence to the treatment regimen.
5. Overall Effect on HIV Replication
The overall effect of darunavir is to significantly reduce the ability of HIV to replicate. By blocking the protease enzyme, darunavir prevents the formation of infectious viral particles, leading to a reduction in plasma viral load (the amount of HIV RNA detectable in the blood). Over time, this helps to preserve the immune system, prevent the progression to AIDS, and reduce the risk of HIV transmission.
Summary of Darunavir's Mechanism of Action:
Inhibits HIV-1 protease: Prevents the enzyme from processing viral polyproteins.
Blocks viral maturation: Results in the production of non-infectious, immature viral particles.
High resistance barrier: Reduces the likelihood of HIV developing resistance to the drug.
Used in combination: Darunavir is typically part of a combination therapy regimen to enhance efficacy and prevent resistance.
In conclusion, darunavir is an HIV protease inhibitor that works by interfering with the maturation of HIV particles, preventing the virus from replicating and spreading. It is a potent drug that is effective in both treatment-naive and treatment-experienced patients, especially those with resistant strains of HIV. Its use as part of combination therapy ensures more effective suppression of the virus and improves long-term outcomes for individuals living with HIV.
Factory
1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.
2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.
Certificate
Package
Logistics Update
In addition to guaranteeing product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
Company's Profile
Xi'an Sonwu Biotech Co., Ltd is a professional Chinese manufacturer and products supplier. It was founded in 2012 and is located in the Hi-Tech Industrial Zone, Xi'an City, Shannxi Province, China. It pays all attention to the development, research, and production of food additives, plants, extract, APl, and other ingredients of health care products. The company supplies five kinds of raw material products: Anti-hair loss Powders, Nootropic, API, Muscle Building products, and Plant Extract. Xi'an Sonwu sincerely believes that the premise of great cooperation is the best service and good quality. So, welcome your inquiry when you need Darunavir Ethanolate Powder.
And if you want to know the Darunavir Ethanolate API price, please contact XI'an Sonwu.
Email: sales@sonwu.com
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