BAM 15 Capsule

BAM15 Supplements

BAM 15 capsule is a Bam 15 supplement provided by Xi'an Sonwu, available in powder and capsule form.Mitochondrial Protonophore BAM 15 is the full name of a small molecular molecule that belongs to the mitochondrial protonophore. It is being researched as a possible anti-obesity and metabolic regulator because it selectively uncouples mitochondrial oxidative phosphorylation (OXPHOS). It increases energy consumption by increasing proton leak in mitochondria without causing an increase in appetite. Independent of ATP synthesis, it can increase mitochondrial proton reflux, which enables cells to burn more energy to maintain homeostasis. According to studies, it can improve metabolic health by lowering oxidative stress and inflammation while also raising energy expenditure and decreasing fat storage without increasing food intake. Compared with traditional uncouplers (such as DNP), BAM15 is safer because it does not cause overheating or other serious side effects. If you need BAM 15, Xi'an Sonwu can supply it. Xi'an Sonwu is looking forward to hearing from you.

Certificate Of Analysis

Product name	BAM 15
CAS NO	210302-17-3
Molecular formula	C16H10F2N6O
Molecular weight	340.29
Quantity	100g
Batch NO	SW250120
Production date	2025.01.21
Expiry Date	2027.01.20
Test based on enterprise standard
Test Item	Specification	Result
HNMR	Consistent with structure	Consistent with structure
HPLC	Consistent with structure	Consistent with structure
Purity	99%	99.89%

Bam 15 Price

Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and the health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw material. Besides, we handle every detail and reduce costs to the maximum so our customers can get cost-effective products. Based on these, customers have given a lot of good feedback about our products. So look for Xi'an Sonwu Biotech Co. Ltd. when buying BAM 15.

Xi'an Sonwu ensures product quality and can provide samples. Here is the quantity.

Customers' Good Comment

OEM Service

Xi'an Sonwu can supply high-quality BAM 15 powder and its capsules.

So customers can customize the capsules they want. The items below can be supplied.

Customized capsule shells (size, color, material)

Customized bottles(size, color, material, style)

Customized packaging(vacuum foil packaging, box, drum)

Customized label(paint film, matte film, optical mask)

What Is The Mechanism Of Action Of Bam15

BAM 15 is a selective mitochondrial protonophore that dissociates mitochondrial oxidative phosphorylation (OXPHOS) without directly blocking the electron transport chain (ETC), which is critical to its mode of action (MoA). Here is a detailed explanation:

1. Mitochondrial Uncoupling

Proton Shuttling:

BAM 15 transports protons (H⁺ ions) across the inner mitochondrial membrane (IMM) from the intermembrane space into the matrix, bypassing ATP synthase (Complex V). This dissipates the proton gradient (proton motive force, PMF) that drives ATP production.

Mild Uncoupling:

BAM 15 causes regulated uncoupling, which raises mitochondrial respiration while decreasing ATP yield, in contrast to harsh uncouplers (like 2,4-DNP). Rather than being stored as ATP, energy is dissipated as heat.

2. Metabolic Effects

Increased Substrate Oxidation:

Cells increase glucose metabolism and fatty acid oxidation (FAO) to compensate for decreased ATP efficiency. This restores energy levels and encourages metabolic flexibility.

Reduced ROS Production:

By lowering the PMF, BAM 15 decreases electron leakage from the ETC, thereby reducing the generation of reactive oxygen species (ROS) and oxidative stress.

3. Downstream Consequences

Anti-Obesity:

Enhanced energy expenditure (via futile cycles) may reduce adiposity and improve insulin sensitivity in metabolic disorders.

Anti-Inflammatory:

Attenuates NLRP3 inflammasome activation by modulating mitochondrial ROS and calcium flux, potentially mitigating chronic inflammation.

Cardioprotective & Neuroprotective:

Improved mitochondrial function and reduced oxidative damage may benefit diseases like heart failure or neurodegeneration.

4. Selectivity & Advantages

Targets Mitochondria: Unlike global uncouplers, BAM 15 preferentially acts on mitochondria with minimal off-target effects.

Lower Toxicity: Compared to classical uncouplers (e.g., DNP), it shows a wider therapeutic window in preclinical models.

5. Key Studies Supporting the MoA

Kenwood et al. (2018) (Cell Reports): Demonstrated BAM 15's ability to uncouple mitochondria without inhibiting ETC complexes.

Hafner et al. (2019) (JBC): Linked its uncoupling activity to reduced ROS and improved metabolic health in mice.

What Are The Benefits Of BAM15

BAM15 is a mitochondrial uncoupler that increases energy expenditure without causing excessive heat production. It has several potential benefits in metabolic health and disease prevention:

1. Anti-Obesity Effects

Increases Energy Expenditure – BAM15 boosts caloric burn by increasing mitochondrial activity.

Promotes Fat Loss – Enhances fatty acid oxidation, reducing body fat accumulation.

No Appetite Increase – Unlike traditional weight-loss drugs, BAM15 does not stimulate hunger.

Potential Use: A safer alternative to traditional stimulants for weight management.

2. Improves Metabolic Health

Enhances Insulin Sensitivity – Reduces insulin resistance, potentially benefiting individuals with type 2 diabetes.

Lowers Blood Sugar Levels – Helps regulate glucose metabolism, reducing hyperglycemia risk.

Reduces Lipid Accumulation – May prevent fatty liver disease by enhancing fat metabolism.

Potential Use: Treating metabolic disorders like diabetes and non-alcoholic fatty liver disease (NAFLD).

3. Anti-Aging and Longevity

Reduces Oxidative Stress – Lowers reactive oxygen species (ROS), preventing cellular damage.

Enhances Mitochondrial Function – Supports mitochondrial health, which declines with age.

May Extend Lifespan – Similar to other mitochondrial uncouplers, BAM15 could delay aging-related diseases.

Potential Use: Slowing down aging and improving overall cellular health.

4. Anti-Inflammatory & Protective Effects

Reduces Systemic Inflammation – May lower markers of chronic inflammation linked to obesity and aging.

Protects Against Ischemia-Reperfusion Injury – Potential cardioprotective effects in heart disease.

Neuroprotective Potential – Could benefit neurodegenerative diseases by maintaining mitochondrial health.

Potential Use: Protection against cardiovascular diseases, neurodegenerative disorders, and chronic inflammation.

5. Key Advantage Over Other Uncouplers (e.g., DNP)

Does not cause dangerous hyperthermia (a significant risk with older uncouplers like DNP).

Lower toxicity and better safety profile in preclinical studies.

BAM 15 Dosage

BAM 15 Dosage Guidelines (Preclinical Research)

BAM 15 is used in in vitro (cell studies) and in vivo (animal models) research. Below are typical dosage ranges based on published studies.

1. In Vitro (Cell Culture) Studies

Concentration Range: 1–10 μM (micromolar)

Commonly tested at five μM for metabolic and mitochondrial studies.

Solvent: Dissolve in DMSO (stock solution), then dilute in cell culture media (final DMSO ≤ 0.1%).

Incubation Time: Typically 4–24 hours, depending on the assay.

2. In Vivo (Animal) Studies

Mice & Rats

Oral Administration (Gavage): 5–20 mg/kg/day

Example: 10 mg/kg/day for 7–14 days in obesity/diabetes studies.

Intraperitoneal (IP) Injection: 5–15 mg/kg/day

Example: 10 mg/kg IP in neuroprotection studies.

Duration: Depending on the model, ranges from acute (single dose) to chronic (weeks).

Formulation

Often suspended in 5% DMSO + 10% Tween-80 + 85% saline (or similar vehicles).

For oral dosing, it may be mixed with 0.5% methylcellulose.

3. Key Considerations

Dose Optimization: Effects may vary by strain (e.g., C57BL/6 mice vs. Sprague-Dawley rats). Pilot studies are recommended.

Toxicity: No severe toxicity was reported in preclinical doses, but weight and behavior were monitored.

Fasting State: Some studies administer BAM 15 after a 4–6h fast to enhance metabolic effects.

4. Example Protocols from Literature

Obesity/Diabetes Model (Mice):

10 mg/kg/day, oral, 4 weeks → Improved insulin sensitivity & reduced fat mass (Kenwood et al., 2018).

Neuroprotection (Mice):

5 mg/kg, IP, single dose → Reduced stroke damage (Hafner et al., 2019).

Factory

1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.

2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.

Certificate

Packing

Logistics Update

In addition to guaranteeing product quality, the other most vital thing is that clients receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ

1. How to inquire?

We can be reached by phone, email, or social media.

2. How do you guarantee the quality of products?

Each batch must be tested, and COA can be supplied to customers. Additionally, all the products pass the test: HPLC, UV, GC, TLC, etc. We cooperate with third parties as well, like SGS.

3. How do you pack and store?

Pack: Use sealed export-grade drums and vacuum-sealed foil packaging, or pack the goods according to customers' needs.

Storage: You can keep it in a dry and cool place and make it avoid sunlight.

If you want to know about the BAM 15 capsule, you can contact Xi'an Sonwu. Click the email, and then you get high-quality Bam 15 supplements.

Email: sales@sonwu.com

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