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99 Powder Bimatoprost

99 Powder Bimatoprost

Appearance: White or almost white crystalline powder
Specification: 99.0%
CAS: 155206-00-1
Molecular Formula: C25H37NO4
Molecular Weight: 415.57
Shelf Life: 2 Years Proper Storage
Stock: Adequate Stock
Certificate: COA,ISO,GMP, HACCP,SGS
Service: OEM Service(Private Package)

Product Introduction

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of 99 powder bimatoprost in China. We warmly welcome yuo to wholesale bulk 99 powder bimatoprost for sale here from our factory. Quality products and reasonable price are available.

 

What Kind Of Drug Is Bimatoprost
99 powder bimatoprost, or Latisse or Lumigan, belongs to a group of drugs called prostamides, synthetic structural analogs of prostaglandins. It can reduce low intraocular pressure and has proven effective in conditions such as ocular hypertension and glaucoma. It was first used to treat eye diseases such as glaucoma. However, during the treatment process, the patient unexpectedly discovered that the diameter, length, and density of his eyelashes had increased significantly, so it is also used to treat sparse eyelashes or sparse eyelash growth. Initially approved by the FDA in 2001 to treat ocular hypertension, it was later approved in 2008 to treat ptosis as eyelash growth became a desirable side effect for patients taking the drug.
Lumigan is recommended for treating hypotrichosis, a significant risk factor for visual field abnormalities associated with glaucoma, and to lower increased intraocular pressure in individuals with open-angle glaucoma or ocular hypertension. Intraocular stress and the likelihood of optic nerve injury, which can result in significant visual impairment, are correlated linearly. As a result, conditions such as ocular hypertension and glaucoma can cause dangerous increases in intraocular pressure. Lumigan rapidly reduces intraocular stress and the risk of visual field defects caused by ocular hypertension of all causes. This medication may also cause gradual changes in the coloring of the iris, eyelids, and lashes, as well as changes in the thickness and development of the lashes. It is considered to be the most potent topical anti-glaucoma drug that lowers IOP at present. It is effective for ordinary people, POAG, and OHT patients. It is mainly used for POAG or OHT patients who cannot tolerate other IOP-lowering drugs or are ineffective when using other IOP-lowering medicines. If you are interested in eye disease treatment products and want to buy bimatoprost, Xi'an Sonwu must be your best choice.

Bimatoprost structure

 

Certificate Of Analysis

ANALYSIS

SPECIFICATION

RUSULT

Appearance

White or almost white crystalline powder

Complies

IR absorbance speatrum

Both speatrum of the test sample and reference standard exhibit the same intensity of absorption at the same wave number

Complies

Water

≤1.0%

0.40%

Optical Rotation

(α)20D:+33.0°~-39.0°(C=1.0,CH3CN)

36.8°

Ethanol

≤0.50%

N.D

Methyl-tert-butylether

≤0.50%

0.05%

Ethyl acetate-

≤0.50%

N.D.

Purity(HPLC)

≥99.0%

99.97%

Conclusion

Conform with specification


How To Buy Bimatoprost Online
Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and the health industry. Insisting on faith-based and quality first is our company's principle. Xi'an Sonwu strictly controls product quality, which means selection starts from raw materials. Besides, Xi'an Sonwu handles every detail and reduce the cost to the maximum extent so our customers can get cost-effective product. Based on these, customers have given much good feedback to our products. So look for Xi'an Sonwu Biotech Co. Ltd. when buying it.
Xi'an Sonwu ultimately ensures product quality but also offers glaucoma powder bimatoprost samples. Here is the quantity.

Form

Sample Amount

MOQ

Powder

1g

1g


Customers's Good Comment

-301


How Does Bimatoprost Work
The mechanism of action of Lumigan is primarily to mimic the effects of prostaglandins, specifically prostaglandin F2α. By slightly increasing the outflow of aqueous humor, it lowers the risk of optic nerve injury and relieves high intraocular pressure. Excessive accumulation of aqueous humor, the fluid in the eye, can cause intraocular pressure to rise, damaging the optic nerve and vision. Lumigan promotes the discharge of aqueous humor by stimulating specific receptors (i.e., prostaglandin and FP receptors), thereby reducing the accumulation of aqueous humor in the eye and lowering intraocular pressure. Lumigan lowers intraocular pressure (IOP) in humans by increasing aqueous humor outflow via the uveoscleral and trabecular meshwork.
It achieves this effect by lowering tomographic resistance to aqueous humor outflow. It does not affect aqueous humor production. Lumigan is hydrolyzed in the eye to its active form, bimatoprost acid. In addition to increasing the drainage of aqueous humor, it inhibits ciliary body cells from producing excess aqueous humor. The ciliary body is the central part of the eye that makes aqueous humor. Lumigan reduces the production of aqueous humor by regulating the ion channel activity in ciliary body cells, thereby lowering intraocular pressure. The chamber angle is the channel through which aqueous humor flows out of the eyeball. It can improve the drainage of aqueous humor by promoting the relaxation and expansion of the chamber angle. It increases the opening of the channel by affecting the contraction and relaxation of cells in the angle tissue, allowing the aqueous humor to flow out of the eye more smoothly.
Another important mechanism of action is that it can extend the growth cycle of eyelashes. The eyelash growth cycle includes the growth phase, resting phase, and shedding phase. Lumigan prolongs the growth phase of eyelashes and promotes the growth of new eyelashes, thereby increasing the length and thickness of eyelashes. Upon systemic absorption, it undergoes oxidation, N-demethylation, and glucuronidation, resulting in various metabolites. In vitro studies indicate that CYP3A4 is an enzyme involved in the metabolism of it.

how does bimatoprost work

 

Bimatoprost Uses
99 powder bimatoprost has several uses in the medical field. The main benefits of it include:

 

1. Treatment of glaucoma
Patients with ocular hypertension or open-angle glaucoma are frequently treated with it to lower intraocular pressure. It reduces stress and guards against optic nerve damage by promoting the evacuation of aqueous fluid from the eye. One study found that intraocular pressure was significantly reduced in patients who used it to treat glaucoma. The study included hundreds of glaucoma patients and observed their intraocular pressure after using it. The results showed that intraocular pressure in the Lumigan treatment group decreased by approximately 20% to 30% on average. Another study compared it to other commonly used intraocular pressure-lowering drugs in treating glaucoma. Research results show that it has similar efficacy to other drugs in reducing intraocular pressure and, in some cases, is even more significant.

glaucoma

 

2. Treatment of high intraocular pressure
Intraocular hypertension is a condition in which the pressure inside the eye increases, and if left untreated, it can lead to glaucoma. One study compared the effectiveness of it and mifepristone, another commonly used intraocular pressure-lowering drug, in treating patients with ocular hypertension. The study included hundreds of patients with ocular hypertension and compared the effectiveness of the two drugs. The results showed that the intraocular pressure of the treatment group was significantly reduced, and the antihypertensive effect was equivalent to or even better than that of the mifepristone group. Another study looked at the effectiveness of it in long-term treatment of glaucoma patients. The study included hundreds of glaucoma patients and followed them for up to a year. The results showed that the intraocular pressure in the Lumigan treatment group remained low for a long time, and it had a sustainable antihypertensive effect in most patients.


3. Treatment of hypotrichosis
Regulatory agencies approve it for hypotrichosis (lack of or insufficient eyelashes). It helps promote eyelash growth by extending the anagen phase and increasing hair count. Because of its effect on eyelash growth, it is also used for cosmetic purposes, primarily to increase eyelash length, thickness, and darkness.
One clinical study looked at patients who used it to treat sparse eyelashes. In this study, patients applied it daily to the base of their eyelashes on their upper eyelids. According to the findings, patients receiving it had noticeably longer and thicker eyelashes than those receiving a placebo after 16 weeks of treatment. Another study compared the effectiveness of other eyelash growth promoters. The study included patients with sparse eyelashes treated with different therapies to promote eyelash growth. Study results showed that patients who used it saw their eyelashes grow faster and significantly increase in length and thickness.

eyelash growth

 

Bimatoprost Class
They commonly used drugs for glaucoma.
1. Prostaglandin derivatives such as latanoprost (Xalatan) and travoprost increase the uveoscleral outflow of aqueous humor. Lumigan also increases trabecular flow.
2. Topical β-adrenergic receptor antagonists such as timol, levobunolol, and betaxolol reduce the production of aqueous humor in the ciliary body.
3. Alpha2-adrenoceptor agonists such as brimonidine work by a dual mechanism, reducing water production and increasing trabecular outflow.
4. A decrease in selectivity similar to epinephrine and dipivefrin increases aqueous humor outflow through the trabecular meshwork and possibly through the uveoscleral outflow pathway, possibly by the action of a β2-receptor agonist.
5. Parasympathomimetics, such as the ciliary muscle contraction of Roca, tighten the trabeculae and allow increased aqueous humor outflow. Ecothiopate is used in chronic glaucoma.
6. Carbonic anhydrase inhibitors such as dorzolamide and Perimin reduce the secretion of aqueous humor by inhibiting carbonic anhydrase in the ciliary body. Acetazolamide.
7. In addition, delayed gastric emptying and glaucoma are treated with physostigmine.

 

Factory
1. Xi'an Sonwu Biotech Co., Ltd has a factory to produce, manufacture, and store the products, so it has adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.

302


Certificate

303

 

Package

304

 

Logistics

-302

Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

logistics


FAQ
Side Effects
(1) Darkening of iris color, blepharitis, eye irritation symptoms, and pain; darkening, thickening, and growth of eyelashes; conjunctival congestion, temporary punctate corneal epithelial erosion, eyelid edema, and erythema; rash.
(2) Rare respiratory disorders, asthma exacerbation, iritis, uveitis, and eyelid skin darkening.
(3) Chest pain and pharyngitis are sporadic.
(4) Eye itching, allergic conjunctivitis, cataracts, conjunctival edema, discharge, photophobia, superficial punctate keratitis, headache, and hypertension.

If you want to know the glaucoma powder bimatoprost manufacturer, you can contact Xi'an Sonwu. Click the email, and then you get high-quality 99 powder bimatoprost.
Email: sales@sonwu.com

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